Novel benzothiazolyl urea and thiourea derivatives with potential cytotoxic and antimicrobial activities
Novel benzothiazolyl urea and thiourea derivatives with potential cytotoxic and antimicrobial activities
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DOI：
10.1080/14756360600991082
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发表时间：
2007-02-01
影响因子：
5.6
通讯作者：
Morsy, Mohamed A.
中科院分区：
文献类型：
--
作者：
Abdel-Rahman, Hamdy M.;Morsy, Mohamed A.
A novel series of benzothiazole urea and thiourea derivatives was synthesized and evaluated for its in vitro cytotoxicity against MCF-7 breast cancer cells. The N-1-(benzothiazol-2-yl)-N-3-morpholinourea 3 displayed the highest cytotoxic activity in this series. A docked pose of 3 was obtained bound to G-quadruplex of human telomere DNA active site using the Molecular Operating Environment (MOE) module. Moreover, the synthesized compounds were screened for their antimicrobial activity against Mycobacterium tuberculosis H37Rv, E. coli, S. aureus and C. albicans. Again, 3 showed the best activity against M. tuberculosis H37Rv while other compounds were equipotent with ampicillin against S. aureus and E. coli.
