Phosphorylation regulates cullin-based ubiquitination in tumorigenesis.
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis.
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DOI：
10.1016/j.apsb.2020.09.007
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Ying M
中科院分区：
文献类型：
--
作者：
Chen Y;Shao X;Cao J;Zhu H;Yang B;He Q;Ying M
Cullin-RING连接酶（Cullin-RING ligases，CRL）识别底物并与底物相互作用以进行泛素化和降解，并且当底物的异常表达涉及病理过程时可以被靶向用于疾病治疗。CRLs的底物或受体的磷酸化可以改变它们之间的相互作用。磷酸化依赖的泛素化和蛋白酶体降解影响各种细胞过程，并可能导致各种疾病的发生，最常见的是肿瘤发生。这些过程有可能通过调节相关激酶的活性以及沿着调节特定癌蛋白和肿瘤抑制因子的稳定性而用于肿瘤干预。本文综述了磷酸化和泛素化之间的相互作用机制、生物学功能及其对肿瘤发生的影响，以期为肿瘤治疗提供新的方向和策略。本文综述了磷酸化和泛素化之间的串扰在不同的生物过程和疾病，主要是癌症，并强调了串扰在肿瘤治疗的治疗潜力。
Cullin-RING ligases (CRLs) recognize and interact with substrates for ubiquitination and degradation, and can be targeted for disease treatment when the abnormal expression of substrates involves pathologic processes. Phosphorylation, either of substrates or receptors of CRLs, can alter their interaction. Phosphorylation-dependent ubiquitination and proteasome degradation influence various cellular processes and can contribute to the occurrence of various diseases, most often tumorigenesis. These processes have the potential to be used for tumor intervention through the regulation of the activities of related kinases, along with the regulation of the stability of specific oncoproteins and tumor suppressors. This review describes the mechanisms and biological functions of crosstalk between phosphorylation and ubiquitination, and most importantly its influence on tumorigenesis, to provide new directions and strategies for tumor therapy. This review summarizes the crosstalk between phosphorylation and ubiquitination in different biological processes and diseases, mainly cancers, and highlights the therapeutic potential of the crosstalk in tumor treatments.
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影响因子：
30.8
作者：
Carver, Brett S.;Tran, Jennifer;Gopalan, Anuradha;Chen, Zhenbang;Shaikh, Safa;Carracedo, Arkaitz;Alimonti, Andrea;Nardella, Caterina;Varmeh, Shohreh;Scardino, Peter T.;Cordon-Cardo, Carlos;Gerald, William;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo
影响因子：
16
作者：
Gan W;Dai X;Lunardi A;Li Z;Inuzuka H;Liu P;Varmeh S;Zhang J;Cheng L;Sun Y;Asara JM;Beck AH;Huang J;Pandolfi PP;Wei W
通讯作者：
Wei W
影响因子：
4.8
作者：
Bradley, Shirley E.;Johnson, Alyssa E.;Burnatowska-Hledin, Maria
通讯作者：
Burnatowska-Hledin, Maria
影响因子：
6.2
作者：
Chae, Unbin;Lee, Heejin;Min, Sang-Hyun
通讯作者：
Min, Sang-Hyun
DOI：
10.1073/pnas.1305687110
发表时间：
2013-09-17
影响因子：
11.1
作者：
Baird, Liam;Lleres, David;Dinkova-Kostova, Albena T.
通讯作者：
Dinkova-Kostova, Albena T.