Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy.
Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy.
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DOI：
10.3402/pba.v6.32221
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Drosatos K
中科院分区：
文献类型：
--
作者：
Drosatos K
Age-related cardiomyopathy accounts for a significant part of heart failure cases. Imbalance of the energetic equilibrium of the heart along with mitochondrial dysfunction and impaired β-adrenergic receptor signaling contributes in the aggravation of cardiac function in the elderly. In this review article, studies that correlate cardiac aging with lipotoxicity are summarized. The involvement of inhibition of peroxisome proliferator-activated receptor-α, β-adrenergic receptor desensitization, and mitochondrial dysfunction as underlying mechanisms for the lipid-driven age-related cardiomyopathy are presented with the aim to indicate potential therapeutic targets for cardiac aging.
