SCANNING ELECTRON-MICROSCOPY OF NORMAL HUMAN SCAR TISSUE AND KELOIDS
SCANNING ELECTRON-MICROSCOPY OF NORMAL HUMAN SCAR TISSUE AND KELOIDS
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DOI：
10.1002/bjs.1800631024
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发表时间：
1976-01-01
影响因子：
9.6
通讯作者：
FINLAY, JB
中科院分区：
文献类型：
--
作者：
HUNTER, JAA;FINLAY, JB
用扫描电镜观察了5例1周龄~ 1岁正常人瘢痕和4例瘢痕疙瘩的纤维结构。在正常伤口中，随着瘢痕成熟，原纤维和纤维取向以及聚集模式发生显著变化，表明重塑持续数月。伤口的边缘和中心也有很大的不同。这些变化可能与施加在成纤维细胞上的应力有关，成纤维细胞通过以抵抗这些力的方式排列胶原蛋白而做出反应。这表明，瘢痕疙瘩成纤维细胞可能缺乏这种能力，以适当的方向应力。
The fibrous architecture of 5 normal human scars between 1 week and 1 year old and 4 keloid scars has been studied by scanning electron microscopy. In normal wounds, significant changes in fibril and fibre orientations and mode of aggregation take place as the scars mature, indicating that remodelling carries on for many months. There are also major differences between the edge and centre of the wound. These changes can be related to the stresses placed on the fibroblasts which have responded by laying down collagen aligned in such a way as to resist these forces. It is suggested that keloid fibroblasts may lack this ability to respond appropriately to orientational stress.