Notch Signaling in B Cell Immune Responses.
Notch Signaling in B Cell Immune Responses.
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Notch信号在B细胞免疫反应中的作用。
DOI：
10.3389/fimmu.2020.609324
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发表时间：
2020
影响因子：
7.3
通讯作者：
Garrett-Sinha LA
中科院分区：
文献类型：
--
作者：
Garis M;Garrett-Sinha LA
Notch信号通路在进化上高度保守，决定细胞命运决定并影响产生免疫系统细胞的祖细胞的存活和生长。Notch信号传导在造血干细胞维持和T谱系细胞特化中的作用已被充分描述。Notch信号传导在B细胞中也起重要作用。特别地，其是边缘区类型B细胞的特化所需要的，但是Notch信号传导在B细胞发育和活化的其它阶段中也是重要的。本文综述了Notch信号通路在B淋巴细胞系定型过程中的作用，以及Notch在成熟B细胞免疫应答中的作用。
The Notch signaling pathway is highly evolutionarily conserved, dictating cell fate decisions and influencing the survival and growth of progenitor cells that give rise to the cells of the immune system. The roles of Notch signaling in hematopoietic stem cell maintenance and in specification of T lineage cells have been well-described. Notch signaling also plays important roles in B cells. In particular, it is required for specification of marginal zone type B cells, but Notch signaling is also important in other stages of B cell development and activation. This review will focus on established and new roles of Notch signaling during B lymphocyte lineage commitment and describe the function of Notch within mature B cells involved in immune responses.