Temporal characteristics of tract-specific anisotropy abnormalities in schizophrenia.
Temporal characteristics of tract-specific anisotropy abnormalities in schizophrenia.
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DOI：
10.1097/wnr.0b013e32830abc35
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发表时间：
2008-09-17
期刊：
影响因子：
1.7
通讯作者：
Davis KL
中科院分区：
文献类型：
--
作者：
Carpenter DM;Tang CY;Friedman JI;Hof PR;Stewart DG;Buchsbaum MS;Harvey PD;Gorman JG;Davis KL
白色物质异常已被检测到使用扩散张量成像（DTI）在不同的位置在大脑中的精神分裂症患者。包括首次发作患者的研究报告不太严重或没有异常，但慢性患者的缺陷更明显。在这里，我们调查了一个非常大的精神分裂症患者群体中的这些异常，这些精神分裂症患者在年龄和病程上都有很大的差异。一个高度可重复的DTI纤维束成像技术被用来量化的分数各向异性的胼胝体以及双侧锥体束的压部和胼胝体。我们发现，分数各向异性下降，相关的疾病的持续时间在胼胝体，但不是在锥体束的压部。研究结果表明，有白色物质束特定的退行性机制，可能存在于疾病发作的点，并在整个疾病的进展。
White matter abnormalities have been detected using diffusion tensor imaging (DTI) in a variety of locations in the brains of patients with schizophrenia. Studies that included first-episode patients report less severe or no abnormalities but more pronounced deficits in chronic patients. Here we investigated these abnormalities in a very large group of schizophrenia that had both large ranges in age and in duration of illness. A highly reproducible DTI-tractography technique was used to quantify the fractional anisotropy of the genu and splenium of the corpus callosum as well as the bilateral pyramidal tracts. We found a decline in fractional anisotropy that correlated with the duration of illness in the genu and splenium of the corpus callosum but not in the pyramidal tracts. The findings suggest that there are white matter tract-specific degenerative mechanisms that may be present at the point of illness onset and that progress throughout the illness.