PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.
PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.
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DOI：
10.1042/bj20080035
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发表时间：
2008-06-15
期刊：
影响因子：
--
通讯作者：
Jayaraman PS
中科院分区：
文献类型：
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作者：
Soufi A;Jayaraman PS
PRH（proline-rich homeodomain）[也称为Hex（haematopoietically expressed homeobox）]蛋白是脊椎动物发育的关键调节因子。PRH能够调节细胞增殖和分化，并且是脊椎动物体轴、造血和血管系统以及许多重要器官形成所需的。PRH是一种DNA结合蛋白，可以通过多种机制抑制和激活其靶基因的转录。此外，PRH可以调节特定mRNA的核转运，使PRH成为在转录和翻译水平上控制基因表达的一组选定蛋白质的成员。最近的生物物理分析的PRH蛋白质表明，它形成同源寡聚复合物在体内和体外，富含脯氨酸的区域的PRH形成一种新的二聚化界面。在这里，我们将审查目前的文献PRH和讨论复杂的网络集中在这个多功能蛋白质的相互作用。
The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development. PRH is able to regulate cell proliferation and differentiation and is required for the formation of the vertebrate body axis, the haematopoietic and vascular systems and the formation of many vital organs. PRH is a DNA-binding protein that can repress and activate the transcription of its target genes using multiple mechanisms. In addition, PRH can regulate the nuclear transport of specific mRNAs making PRH a member of a select group of proteins that control gene expression at the transcriptional and translational levels. Recent biophysical analysis of the PRH protein has shown that it forms homo-oligomeric complexes in vivo and in vitro and that the proline-rich region of PRH forms a novel dimerization interface. Here we will review the current literature on PRH and discuss the complex web of interactions centred on this multifunctional protein.