Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?
Epigenetic regulation of transcription: a mechanism for inducing variations in phenotype (fetal programming) by differences in nutrition during early life?
复制标题
转录的表观遗传调节：一种通过早期营养的差异来诱导表型（胎儿编程）变化的机制？
DOI：
10.1017/s0007114507682920
复制
发表时间：
2007-06
影响因子：
3.6
通讯作者：
Lillycrop, Karen A.
中科院分区：
文献类型：
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作者：
Burdge, Graham C.;Hanson, Mark A.;Slater-Jefferies, Jo L.;Lillycrop, Karen A.
有相当多的证据表明，不同的表型诱导的早期生活环境的变化，包括营养，这在人类与代谢疾病的分级风险;胎儿编程。早期生活环境的差异诱导组织结构和功能的持续变化可能涉及基因转录调控的终身改变。这一观点得到了人类和动物模型研究的支持。基因表达发生这种变化的机制现在开始被理解。在这篇综述中，我们讨论了转录的表观遗传调控的变化，特别是DNA甲基化和组蛋白的共价修饰，在诱导早期生活中的营养约束改变表型的作用。在表型诱导中改变基因的表观遗传调节的证明表明，干预措施可能会改变与早期营养不平衡相关的长期疾病风险。
There is considerable evidence for the induction of different phenotypes by variations in the early life environment, including nutrition, which in humans is associated with graded risk of metabolic disease; fetal programming. It is likely that induction of persistent changes to tissue structure and function by differences in the early life environment involves life-long alterations to the regulation of gene transcription. This view is supported by both studies of humans and animal models. The mechanism which underlies such changes to gene expression is now beginning to be understood. In this review we discuss the role of changes in the epigenetic regulation of transcription, specifically DNA methylation and covalent modification of histones, in the induction of an altered phenotype by nutritional constraint in early life. Demonstration of altered epigenetic regulation of genes in phenotype induction suggests the possibility of interventions to modify long-term disease risk associated with unbalanced nutrition in early life.