A Versatile and Scalable Strategy to Discrete Oligomers.
A Versatile and Scalable Strategy to Discrete Oligomers.
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DOI：
10.1021/jacs.6b03127
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发表时间：
2016-05-18
影响因子：
15
通讯作者：
Hawker CJ
中科院分区：
文献类型：
--
作者：
Lawrence J;Lee SH;Abdilla A;Nothling MD;Ren JM;Knight AS;Fleischmann C;Li Y;Abrams AS;Schmidt BV;Hawker MC;Connal LA;McGrath AJ;Clark PG;Gutekunst WR;Hawker CJ
据报道，一种通用策略用于从市售单体家族（例如丙烯酸酯、苯乙烯、硅氧烷）合成多克的离散低聚物。该策略的核心是确定使用自动快速色谱系统分离低聚物混合物的可重复程序，并通过离散低聚物文库的多克制备证明了该方法的有效性（Đ = 1.0）。合成的可用性，加上精确的结构控制，使得这些功能构件能够用于基础研究和有针对性的技术应用。
A versatile strategy is reported for the multi-gram synthesis of discrete oligomers from commercially available monomer families, e.g., acrylates, styrenics, siloxanes. Central to this strategy is the identification of reproducible procedures for the separation of oligomer mixtures using automated flash chromatography systems with the effectiveness of this approach demonstrated through the multi-gram preparation of discrete oligomer libraries (Đ = 1.0). Synthetic availability, coupled with accurate structural control, allows these functional building blocks to be harnessed for both fundamental studies as well as targeted technological applications.