Niacin skin flushing in schizophrenic and depressed patients and healthy controls
Niacin skin flushing in schizophrenic and depressed patients and healthy controls
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DOI：
10.1016/j.psychres.2005.10.010
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发表时间：
2006-08-30
影响因子：
11.3
通讯作者：
van den Bosch, Robert J.
中科院分区：
文献类型：
--
作者：
Bosveld-van Haandel, Linda;Knegtering, Rikus;van den Bosch, Robert J.
本文比较了16例精神分裂症患者、17例抑郁症患者和16例健康对照者的皮肤对烟酸潮红试验的反应。烟酸甲酯（烟酸）的浓度为0.1 M的应用于前臂5分钟。显着差异，可以观察到组之间的精神分裂症患者（少冲洗）相比，其他组。抑郁症患者和健康对照组之间的烟酸潮红没有统计学差异。性别、年龄和抗精神病药物的使用似乎不是混杂因素。然而，精神分裂症患者组内潮红的差异是惊人的。大多数患者表现出很少或没有潮红，但有些患者反应强烈。尽管可以通过尼克酸潮红试验区分这三组，但为了开发该试验的可靠临床应用，还需要进一步的研究。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
This study compares the skin reactions to the niacin flushing test of 16 schizophrenic patients with those of 17, depressed patients and 16 healthy controls. Methyl nicotinate (niacin) in a concentration of 0.1 M was applied to the forearm for 5 min. Significant differences could be observed between the group of schizophrenic patients (less flushing) in comparison to the other groups. There were no statistical differences in niacin flushing between patients with depression and healthy controls. Gender, age and the use of antipsychotic agents did not appear to be confounders. The differences in flushing within the group of schizophrenic patients were striking, however. Most patients showed little or no flushing, but some patients reacted strongly. Although the three groups could be differentiated by the niacin flushing test, to develop a reliable clinical application of this test, further research is necessary. (c) 2005 Elsevier Ireland Ltd. All rights reserved.