EMT in Breast Carcinoma-A Review.
EMT in Breast Carcinoma-A Review.
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DOI：
10.3390/jcm5070065
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发表时间：
2016-07-14
影响因子：
3.9
通讯作者：
Bartlett JM
中科院分区：
文献类型：
--
作者：
Felipe Lima J;Nofech-Mozes S;Bayani J;Bartlett JM
上皮间质转化（EMT）是一种细胞程序，参与胚胎发育;伤口愈合，但也参与肿瘤发生。乳腺癌（BC）是世界范围内女性最常见的癌症，大多数死亡（90%）是由浸润和转移引起的。EMT在肿瘤的侵袭和转移过程中起重要作用。几种不同的生物学事件整合了一个级联反应，不仅导致从上皮细胞到间充质细胞表型的变化，而且允许分离、迁移、侵入并最终定植在第二个部位。了解EMT的生物学复杂性可以提供重要的见解，从而导致在浸润前和浸润性乳腺癌中开发治疗靶点，并且可以用作识别具有更大的复发、转移和导致死亡的治疗抗性机会的肿瘤子集的生物标志物。
The epithelial to mesenchymal transition (EMT) is a cellular program that is involved in embryonic development; wound healing, but also in tumorigenesis. Breast carcinoma (BC) is the most common cancer in women worldwide, and the majority of deaths (90%) are caused by invasion and metastasis. The EMT plays an important role in invasion and subsequent metastasis. Several distinct biological events integrate a cascade that leads not only to a change from an epithelial to mesenchymal phenotype, but allows for detachment, migration, invasion and ultimately, colonization of a second site. Understanding the biological intricacies of the EMT may provide important insights that lead to the development of therapeutic targets in pre-invasive and invasive breast cancer, and could be used as biomarkers identifying tumor subsets with greater chances of recurrence, metastasis and therapeutic resistance leading to death.