Abnormal Causal Connectivity by Structural Deficits in First-Episode, Drug-Naive Schizophrenia at Rest
Abnormal Causal Connectivity by Structural Deficits in First-Episode, Drug-Naive Schizophrenia at Rest
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首发未用药精神分裂症静息时因结构性缺陷导致的异常因果连接
DOI：
10.1093/schbul/sbu126
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发表时间：
2015-01-01
影响因子：
6.6
通讯作者：
Zhao, Jingping
中科院分区：
文献类型：
--
作者：
Guo, Wenbin;Liu, Feng;Zhao, Jingping
前额叶-丘脑-小脑回路的解剖缺陷和静息态功能连接（FC）改变与精神分裂症的神经生物学有关。然而，精神分裂症的结构缺陷对该回路因果连接的影响仍不清楚。本研究旨在探讨首次发作的首次用药精神分裂症患者的结构缺陷导致的因果连接偏倚。结构和静息态功能磁共振成像（fMRI）数据来自49例首次发作，药物初治精神分裂症患者和50名健康对照。通过基于体素的形态测量和格兰杰因果关系分析来分析数据。前额叶-丘脑（边缘系统）-小脑整合的因果连接首次发作的未用药精神分裂症患者的感觉运动回路部分受到结构缺陷的影响，表现为：（1）单侧前额叶-感觉运动连接异常（增加从左内侧前额叶皮层[MPFC]到感觉运动区域的驱动作用）;（2）双侧边缘-感觉运动连接异常（右前扣带皮层[ACC]对感觉运动区的驱动作用增加，感觉运动区对右前扣带皮层的反馈减少）;（3）感觉运动区之间的因果联系在双侧增加和减少。在患者中也观察到了种子的灰质体积之间的一些相关性，沿着其因果效应和临床变量（未治疗精神病的持续时间和症状严重程度）。研究结果表明，首次发作，药物初治精神分裂症的结构缺陷的前额叶-丘脑（边缘）-小脑（感觉运动）电路的部分影响。精神分裂症可能会加强从左MPFC或右ACC到感觉运动区域的驱动连接，并可能会破坏感觉运动区域之间的双边因果连接。
Anatomical deficits and resting-state functional connectivity (FC) alterations in prefrontal-thalamic-cerebellar circuit have been implicated in the neurobiology of schizophrenia. However, the effect of structural deficits in schizophrenia on causal connectivity of this circuit remains unclear. This study was conducted to examine the causal connectivity biased by structural deficits in first-episode, drug-naive schizophrenia patients. Structural and resting-state functional magnetic resonance imaging (fMRI) data were obtained from 49 first-episode, drug-naive schizophrenia patients and 50 healthy controls. Data were analyzed by voxel-based morphometry and Granger causality analysis. The causal connectivity of the integrated prefrontal-thalamic (limbic)-cerebellar (sensorimotor) circuit was partly affected by structural deficits in first-episode, drug-naive schizophrenia as follows: (1) unilateral prefrontal-sensorimotor connectivity abnormalities (increased driving effect from the left medial prefrontal cortex [MPFC] to the sensorimotor regions); (2) bilateral limbic-sensorimotor connectivity abnormalities (increased driving effect from the right anterior cingulate cortex [ACC] to the sensorimotor regions and decreased feedback from the sensorimotor regions to the right ACC); and (3) bilateral increased and decreased causal connectivities among the sensorimotor regions. Some correlations between the gray matter volume of the seeds, along with their causal effects and clinical variables (duration of untreated psychosis and symptom severity), were also observed in the patients. The findings indicated the partial effects of structural deficits in first-episode, drug-naive schizophrenia on the prefrontal-thalamic (limbic)-cerebellar (sensorimotor) circuit. Schizophrenia may reinforce the driving connectivities from the left MPFC or right ACC to the sensorimotor regions and may disrupt bilateral causal connectivities among the sensorimotor regions.