Depression in late life: age of onset as marker of a subtype.
Depression in late life: age of onset as marker of a subtype.
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DOI：
10.1016/0165-0327(89)90042-6
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发表时间：
1989-09
影响因子：
6.6
通讯作者：
Y. Conwell;J. Nelson;K. Kim;C. Mazure
中科院分区：
文献类型：
--
作者：
Y. Conwell;J. Nelson;K. Kim;C. Mazure
晚发性抑郁症在发病机制和病理学上可能与早发性复发性情感障碍不同。作者回顾了94例连续入院的60岁以上单相抑郁症患者的记录，根据他们的发病年龄将受试者分组，并检查了人口统计学和临床特征。晚发性老年抑郁症患者的情感性疾病家族史发生率较低，住院时间较长，出院时残留症状较多。然而，发病年龄与精神病、精神病、内科疾病、入院时症状严重程度或神经病理学指标之间无明显关系。虽然晚发性老年抑郁症患者的表现不如早发性抑郁症患者，但这些数据并不支持晚发性抑郁症是一种独特的病理过程的观点。
Late-onset depression may be pathogenetically and prognostically distinct from early-onset, recurrent affective disorder. The authors reviewed records of 94 consecutively admitted unipolar major depressives over the age of 60 years, divided subjects into groups based on their age of onset, and examined demographic and clinical features. Late-onset elderly depressives had a lower incidence of family history of affective illness, longer hospital stay, and more residual symptoms at discharge. However, there was no demonstrable relationship between age of onset and presence of psychosis, melancholia, medical illness, symptom severity at admission, or indicators of neuropathology. Although late-onset elderly depressives did less well than those with early-onset illness, the data do not support the notion of late-onset depression as a distinct pathological process.