Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice
Soy Isoflavone Equol Perpetuates Dextran Sulfate Sodium-Induced Acute Colitis in Mice
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DOI：
10.1271/bbb.100710
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发表时间：
2011-03-01
影响因子：
1.6
通讯作者：
Sone, Saburo
中科院分区：
文献类型：
--
作者：
Sakai, Tohru;Furoku, Sakina;Sone, Saburo
研究了大豆异黄酮染料木素、大豆黄酮和雌马酚对实验性结肠炎的影响。马雌酚严重导致葡聚糖硫酸钠（DSS）引起的结肠炎，通过体重减轻来评估。在马酚处理的小鼠中，T细胞产生的抗炎细胞因子IL-10减少。结果表明，大豆异黄酮雌马酚在胃肠道炎症反应中起重要作用。
The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.