Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries.
Teleost microbiomes: the state of the art in their characterization, manipulation and importance in aquaculture and fisheries.
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DOI：
10.3389/fmicb.2014.00207
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发表时间：
2014
影响因子：
5.2
通讯作者：
Derome N
中科院分区：
文献类型：
--
作者：
Llewellyn MS;Boutin S;Hoseinifar SH;Derome N
本土微生物区系在脊椎动物宿主的生活中起着至关重要的作用。在人类和小鼠的模型中，与生俱来的免疫和获得性免疫与共生微生物群的发展密切相关，这一点越来越明显。此外，肠道微生物区系控制着消化和营养新陈代谢的几个方面。对硬骨鱼的研究对微生物学中引入大规模并行测序程序的反应相对较慢。尽管如此，在生物和灵知生物斑马鱼模型方面取得了进展，定义了核心微生物组并描述了其在发育中的作用。然而，对其他硬骨鱼物种的微生物组研究，特别是那些从水产养殖角度来看重要的物种，一直相对缓慢。在这篇综述中，我们考察了迄今为止硬骨鱼微生物组研究的进展。我们讨论硬骨微生物群在健康和疾病中的作用，微生物群的个体发育，成功操纵微生物群的前景(特别是在水产养殖环境中)，并试图确定重要的未来研究主题。我们预测，随着全球对鱼蛋白需求的增加，以及需要找到可持续的方法来提高水产养殖产量，这一领域的研究将出现爆炸性增长。下一代测序技术成本的降低和易用性的提高提供了技术支持，未来10年将是硬骨鱼微生物组研究的激动人心的时期。
Indigenous microbiota play a critical role in the lives of their vertebrate hosts. In human and mouse models it is increasingly clear that innate and adaptive immunity develop in close concert with the commensal microbiome. Furthermore, several aspects of digestion and nutrient metabolism are governed by intestinal microbiota. Research on teleosts has responded relatively slowly to the introduction of massively parallel sequencing procedures in microbiomics. Nonetheless, progress has been made in biotic and gnotobiotic zebrafish models, defining a core microbiome and describing its role in development. However, microbiome research in other teleost species, especially those important from an aquaculture perspective, has been relatively slow. In this review, we examine progress in teleost microbiome research to date. We discuss teleost microbiomes in health and disease, microbiome ontogeny, prospects for successful microbiome manipulation (especially in an aquaculture setting) and attempt to identify important future research themes. We predict an explosion in research in this sector in line with the increasing global demand for fish protein, and the need to find sustainable approaches to improve aquaculture yield. The reduced cost and increasing ease of next generation sequencing technologies provides the technological backing, and the next 10 years will be an exciting time for teleost microbiome research.