Synthesis of different glutathione-sulfur mustard adducts of verified and potential biomarkers
Synthesis of different glutathione-sulfur mustard adducts of verified and potential biomarkers
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DOI：
10.1039/c8ra03360a
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发表时间：
2018-01-01
期刊：
影响因子：
3.9
通讯作者：
Curty, Christophe
中科院分区：
文献类型：
--
作者：
Bielmann, Andreas;Sambiagio, Nicolas;Curty, Christophe
硫芥（SM）是一种用作化学武器的起泡剂。谷胱甘肽（GSH）参与SM的裂解酶降解途径，最近，SM和GSH之间的生物加合物在体外观察。虽然这些生物加合物从未从SM的体内试验或真实的中毒中分离出来，但它们可能是潜在的未来生物标志物，用于暴露的回顾性验证。我们在此报告合成不同的观察到的和新的潜在的GSH-SM生物加合物作为分析研究的参考材料。两种不同的方法进行了研究：积木途径和直接与GSH的反应。这些参考文献的可用性将有助于未来的研究，并可能导致新的GSH-SM生物标志物的发现。
Sulfur Mustard (SM) is a blistering agent used as a chemical weapon. Glutathione (GSH) is involved in the -lyase degradation pathway of SM and recently, bioadducts between SM and GSH were observed in vitro. While these bioadducts have never been isolated from in vivo tests or real poisoning with SM, they could be of interest as potential future biomarkers for the retrospective validation of exposure. We herein report the synthesis of different observed and new potential GSH-SM bioadducts as reference materials for analytical investigation. Two distinct approaches were investigated: a building-block pathway and the direct reaction with GSH. The availability of these references will aid future studies and may lead to the discovery of new GSH-SM biomarkers.