Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons
Curcumin promotes neurite outgrowth via reggie-1/flotillin-2 in cortical neurons
复制标题
姜黄素通过 reggie-1/flotillin-2 促进皮质神经元中的神经突生长
DOI：
10.1016/j.neulet.2013.11.029
复制
发表时间：
2014-01-24
影响因子：
2.5
通讯作者：
Dong, Qiang
中科院分区：
文献类型：
--
作者：
Lu, Zhengyu;Shen, Yan;Dong, Qiang
姜黄素是众所周知的抗氧化剂和抗炎剂。在这项研究中，我们提供了令人信服的证据，姜黄素在皮质神经元突起生长的功能。我们发现姜黄素处理可以促进原代神经元的突起数量、平均突起长度和最大突起长度，而reggie-1 siRNA或细胞外信号调节激酶（ERK）1/2拮抗剂可以抑制这些突起。此外，姜黄素诱导的神经突生长与ERK 1/2磷酸化有关，而ERK 1/2磷酸化被reggie-1敲低所阻断。总之，我们的研究结果表明，姜黄素可以通过reggie-1和ERK 1/2途径介导神经突起的生长。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Curcumin is well known as an antioxidant and anti-inflammatory agent. In this study, we provided convincing evidence for the function of curcumin in neurite outgrowth of cortical neurons. We discovered that curcumin treatment could promote the number of processes, mean process length, and maximum process length of primary neurons, which were inhibited by reggie-1 siRNAs or extracellular signalregulated kinase (ERK) 1/2 antagonist. Furthermore, curcumin-induced neurite growth was related to the ERK1/2 phosphorylation, which was blocked by reggie-1 knockdown. Overall, our results implied that curcumin could mediate neurite outgrowth through reggie-1 and ERK1/2 pathway. (C) 2013 Elsevier Ireland Ltd. All rights reserved.