Adherent-invasive Escherichia coli in inflammatory bowel disease
Adherent-invasive Escherichia coli in inflammatory bowel disease
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DOI：
10.1136/gutjnl-2017-314903
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发表时间：
2018-03-01
期刊：
影响因子：
24.5
通讯作者：
Colombel, Jean-Frederic
中科院分区：
文献类型：
--
作者：
Palmela, Carolina;Chevarin, Caroline;Colombel, Jean-Frederic
肠道菌群失调一直被描述为IBD患者。在过去的几十年里，大肠杆菌，特别是粘附-侵袭性大肠杆菌（AIEC）的病理型与IBD的发病机制有关。自从20年前发现AIEC以来，在揭示这些细菌特征及其与肠道免疫系统的相互作用方面取得了进展。本文综述了AIEC与肠上皮细胞的粘附机制（通过FimH和细胞粘附分子6）及其在巨噬细胞内逃避自噬的能力。我们还探讨了克罗恩病和UC患者中AIEC患病率的现有数据，以及AIEC的存在与疾病部位、活动和术后复发之间的关系。最后，我们强调了针对AIEC在肠道粘膜定植的潜在治疗策略，包括噬菌体治疗、细菌素和抗粘附分子的使用。这些策略可能为今后IBD的预防和治疗开辟新的途径。
Intestinal microbiome dysbiosis has been consistently described in patients with IBD. In the last decades, Escherichia coli, and the adherent-invasive E coli (AIEC) pathotype in particular, has been implicated in the pathogenesis of IBD. Since the discovery of AIEC, two decades ago, progress has been made in unravelling these bacteria characteristics and its interaction with the gut immune system. The mechanisms of adhesion of AIEC to intestinal epithelial cells (via FimH and cell adhesion molecule 6) and its ability to escape autophagy when inside macrophages are reviewed here. We also explore the existing data on the prevalence of AIEC in patients with Crohn's disease and UC, and the association between the presence of AIEC and disease location, activity and postoperative recurrence. Finally, we highlight potential therapeutic strategies targeting AIEC colonisation of gut mucosa, including the use of phage therapy, bacteriocins and antiadhesive molecules. These strategies may open new avenues for the prevention and treatment of IBD in the future.