Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma.
Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma.
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神经生长因子和血管内皮生长因子：63例唾液腺样性囊性癌患者的回顾性分析。
DOI：
10.4248/ijos10005
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发表时间：
2010-03
影响因子：
14.9
通讯作者：
Yan-ning L
中科院分区：
文献类型：
--
作者：
Hao L;Xiao-lin N;Qi C;Yi-ping Y;Jia-quan L;Yan-ning L
目的检测神经生长因子（NGF）和血管内皮生长因子（VEGF）在涎腺腺样囊性癌（SACC）组织中的表达，探讨其与SACC预后的关系。我们回顾了1988年1月至2005年10月间63例SACC手术治疗的病例。免疫组化法检测肿瘤组织中NGF和VEGF的表达。Kaplan-Meier分析和考克斯比例风险回归模型用于评估生存的预测因素。与正常涎腺组织相比，SACC组织中NGF和VEGF均呈高表达（P<0.05），且在实体型、TNM分期、神经浸润和复发组中表达强度更强。NGF和VEGF高表达、实体型、晚期、神经周围浸润、复发和单纯扩大切除者生存率较低（P<0.05）。NGF和VEGF在SACC组织中的表达随浸润转移而增加。NGF和VEGF表达是影响患者生存的独立预后因素。
To detect the expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) in salivary adenoid cystic carcinoma (SACC) tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC. Medical records of 63 patients surgically treated for SACC between January 1988 and October 2005 were reviewed. Immunohistochemistry was performed to examine the expression of NGF and VEGF in tumor tissues. Kaplan-Meier analysis and Cox's proportional hazard regression model were applied to assess predictors of survival. NGF and VEGF were overexpressed in SACC tissues, compared with those in normal salivary tissues (P<0.05), and the staining intensity of these two factors was stronger in groups of solid subtype, advanced TNM stage, perineural invasion and recurrence. Patients with high-expression of NGF and VEGF, solid subtype, advanced stage, perineural invasion, recurrence and extended resection alone had worse survival rates (P<0.05). NGF and VEGF are expressed increasingly in the tissues of SACC cases with invasion and metastasis. NGF expression and VEGF expression are independent prognosis factors for survival.