THE EFFECT OF VARIOUS PHYSICAL PARAMETERS ON THE SIZE AND SHAPE OF NECROSED TISSUE VOLUME DURING ULTRASOUND SURGERY
THE EFFECT OF VARIOUS PHYSICAL PARAMETERS ON THE SIZE AND SHAPE OF NECROSED TISSUE VOLUME DURING ULTRASOUND SURGERY
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DOI：
10.1121/1.408550
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发表时间：
1994-03-01
影响因子：
2.4
通讯作者：
HYNYNEN, K
中科院分区：
文献类型：
--
作者：
DAMIANOU, C;HYNYNEN, K
本研究的目的是测试使用计算的热剂量作为坏死组织体积的预测因子的概念。进行了参数研究，其中超声处理参数（脉冲持续时间，功率），换能器参数（频率，F数）和组织特性（灌注率，衰减）是不同的，并研究其对病变大小的影响。在体内实验中，聚焦超声束被用来诱导组织坏死的狗和兔的大腿肌肉也进行了获得的可靠性的预测。实验和模拟的病变大小比较好。从参数研究的阈值强度为1-和5-s声处理被发现是约1000和400 W/cm（2），分别。研究发现，对于5秒或更短的脉冲，病变大小几乎与灌注无关。病灶大小随脉冲持续时间、声功率和F数的增加而增加，但随频率的增加而减小，前提是焦点强度保持恒定。还发现，焦点在组织中越深，引起焦点区中的选择性组织坏死的频率范围越小。
The purpose of this study was to test the concept of using calculated thermal dose as a predictor for the necrosed tissue volume. A parametric study was conducted where the sonication parameters (pulse duration, power), transducer parameters (frequency, F number) and tissue properties (perfusion rate, attenuation) were varied and their effect on the lesion size was investigated. In vivo experiments where a focused ultrasound beam was used to induce tissue necrosis in thigh muscle of dog and rabbit were also conducted to obtain the reliability of the predictions. The experimental and simulated lesion sizes compared well. From the parametric study the threshold intensity for 1- and 5-s sonications were found to be about 1000 and 400 W/cm(2), respectively. It was found that the lesion size was practically perfusion independent for pulses 5 s or shorter. The lesion size increases with increased pulse duration, acoustical power, and F number, but decreases with increased frequency provided that the focal intensity is kept constant. It was found also that the deeper the focus is in the tissue, the smaller the frequency range that causes selective tissue necrosis in the focal zone.