Chemical constituents from Cassytha filiformis II
Chemical constituents from Cassytha filiformis II
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DOI：
10.1021/np970348g
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发表时间：
1998-07-01
影响因子：
5.1
通讯作者：
Wu, YC
中科院分区：
文献类型：
--
作者：
Chang, FR;Chao, YC;Wu, YC
采用生物活性导向的分级分离方法，从新鲜的木薯药材的甲醇提取物中进一步分离和鉴定了三个新化合物，包括阿朴啡生物碱，cassyformine（4）;氧代阿朴啡生物碱，filiformine（8）和木脂素，（+）-diasyringaresinol（10），沿着14个已知化合物。其中，cathafiline（1）、cathaformine（2）、actinodaphnine（3）、N-甲基actinodaphnine（5）、precentrine（6）和ocoteine（7）具有显著的抗血小板聚集活性。
Using a bioassay-directed fractionation method, three new compounds, including an aporphine alkaloid, cassyformine (4); an oxoaporphine alkaloid, filiformine (8), and a lignan, (+)-diasyringaresinol (10), along with 14 known compounds, were further isolated and characterized from the MeOH extract of the fresh herbs of Cassytha filiformis. Among the isolates of this plant, cathafiline (1), cathaformine (2), actinodaphnine (3), N-methylactinodaphnine (5), predicentrine (6), and ocoteine (7) exhibited significant antiplatelet aggregation activity.