Spinal Circuits Transmitting Mechanical Pain and Itch.

Spinal Circuits Transmitting Mechanical Pain and Itch.
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DOI:
10.1007/s12264-017-0136-z
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发表时间:
2018-03
影响因子:
5.6
通讯作者:
Ma Q
Ma Q
中科院分区:
医学2区
文献类型:
--
作者:
Duan B;Cheng L;Ma Q

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1905年,亨利·海德(Henry Head)首先提出,疼痛相关的原发性病变信息的传递可以受到来自感觉无害触摸和温度的传入神经的输入的负向调节。1965年,Melzak和Wall提出了一个更具体的疼痛门控理论,强调了无髓C纤维和有髓A纤维在疼痛传递中的相互作用。在这里,我们回顾了目前的理解脊髓微电路传输和门控机械疼痛或瘙痒。我们还讨论了门控中断如何引起无害的机械刺激引起的疼痛或瘙痒,这是许多慢性疼痛或瘙痒患者的标志性症状。
In 1905, Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated by inputs from afferents sensing innocuous touch and temperature. In 1965, Melzak and Wall proposed a more concrete gate control theory of pain that highlights the interaction between unmyelinated C fibers and myelinated A fibers in pain transmission. Here we review the current understanding of the spinal microcircuits transmitting and gating mechanical pain or itch. We also discuss how disruption of the gate control could cause pain or itch evoked by innocuous mechanical stimuli, a hallmark symptom for many chronic pain or itch patients.
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