Spinal Circuits Transmitting Mechanical Pain and Itch.
Spinal Circuits Transmitting Mechanical Pain and Itch.
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DOI:
10.1007/s12264-017-0136-z
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发表时间:
2018-03
影响因子:
5.6
通讯作者:
Ma Q
中科院分区:
文献类型:
--
作者:
Duan B;Cheng L;Ma Q
In 1905, Henry Head first suggested that transmission of pain-related protopathic information can be negatively modulated by inputs from afferents sensing innocuous touch and temperature. In 1965, Melzak and Wall proposed a more concrete gate control theory of pain that highlights the interaction between unmyelinated C fibers and myelinated A fibers in pain transmission. Here we review the current understanding of the spinal microcircuits transmitting and gating mechanical pain or itch. We also discuss how disruption of the gate control could cause pain or itch evoked by innocuous mechanical stimuli, a hallmark symptom for many chronic pain or itch patients.
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影响因子:
16.2
作者:
Cui, Lian;Miao, Xuerong;Liang, Lingli;Abdus-Saboor, Ishmail;Olson, William;Fleming, Michael S.;Ma, Minghong;Tao, Yuan-Xiang;Luo, Wenqin
通讯作者:
Luo, Wenqin
DOI:
10.1126/science.aac8653
发表时间:
2015-10-30
期刊:
Science (New York, N.Y.)
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Bourane S;Duan B;Koch SC;Dalet A;Britz O;Garcia-Campmany L;Kim E;Cheng L;Ghosh A;Ma Q;Goulding M
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Ma Q
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通讯作者:
Ririe DG