FLAVONOIDS AND RELATED-COMPOUNDS AS INHIBITORS OF ARACHIDONIC-ACID PEROXIDATION
FLAVONOIDS AND RELATED-COMPOUNDS AS INHIBITORS OF ARACHIDONIC-ACID PEROXIDATION
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DOI：
10.1016/0090-6980(80)90103-3
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发表时间：
1980-01-01
影响因子：
2.9
通讯作者：
WURM, G
中科院分区：
文献类型：
--
作者：
BAUMANN, J;BRUCHHAUSEN, FV;WURM, G
直到新的发现之前，关于类黄酮结构的生化解释的药理作用的数据报道很少。当针对花生四烯酸代谢进行测试时，许多黄酮类化合物对脂氧合酶有效[大豆、大鼠肺和脾][EC。 1.13.11.12.)]和环加氧酶途径。一些类黄酮是环氧合酶或脂氧合酶的主要抑制剂，其他类黄酮对这两种酶同样有效。这些化合物被证明是阐明脂肪酸过氧化问题的有用工具。前列腺素合成酶源自大鼠肾髓质。
Until new only few data have been reported on biochemically explicable pharmacological effects of falvonoid structures. When tested against arachidonic acid metabolism many flavonoids were effective against the lipoxygenase [soybean, rat lung and spleen [EC. 1.13.11.12.)] and cyclo-oxygenase pathways. Some flavonoids were predominant inhibitors of either cyclooxygenase or lipoxygenase, others were equally effective against both enzymes. These compounds proved to be useful tools to elucidate fatty acid peroxidation problems. Prostaglandin synthetase was of rat renal medulla origin.