Human papillomavirus infection of the uterine cervix: histological appearances in 28 cases identified by immunohistochemical techniques.
Human papillomavirus infection of the uterine cervix: histological appearances in 28 cases identified by immunohistochemical techniques.
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子宫颈人乳头瘤病毒感染：免疫组织化学技术鉴定的 28 例组织学表现。
DOI：
10.1136/jcp.37.2.126
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发表时间：
1984
影响因子：
3.4
通讯作者：
Singer,A
中科院分区：
文献类型：
--
作者：
Dyson,JL;Walker,PG;Singer,A
用抗人乳头瘤病毒（HPV）内部衣壳抗原的抗血清处理28例宫颈活检标本时，免疫组化染色呈阳性。对同一组织块相邻切片的组织学检查显示，与已经描述的HPV感染相关的异常范围要大得多。照片通常是诊断性的。它主要依赖于确定挖空细胞-核周晕的细胞，在其核中携带病毒抗原-但异常角化也是一个特征。伴随的上皮检查结果范围从正常到CIN III（宫颈上皮内瘤变）。后者是一个不寻常的，但独特的外观，其中细胞质成熟被保存在一定程度上，但在其中总的细胞核内可见上皮的所有层。
Twenty eight biopsy specimens of the cervix showed positive immunohistochemical staining when treated with an antiserum raised against an internal capsid antigen of human papillomavirus (HPV). Histological examination of adjoining sections from the same blocks showed a much wider range of abnormalities than those already described in association with HPV infection. The picture was usually diagnostic. It rested chiefly on identifying the koilocyte--the cell with the perinuclear halo that carries the viral antigen in its nucleus--but abnormal keratinisation was also a feature. The accompanying epithelial findings ranged from normal to CIN III (cervical intraepithelial neoplasia). The latter was of an unusual but distinct appearance, in which cytoplasmic maturation was preserved to some degree but in which gross nuclear atypia was seen in all layers of the epithelium.