Genetic Alcohol Sensitivity Regulated by ALDH2 and ADH1B Polymorphisms as Indicator of Mental Disorders in Japanese Employees
Genetic Alcohol Sensitivity Regulated by ALDH2 and ADH1B Polymorphisms as Indicator of Mental Disorders in Japanese Employees
复制标题
ALDH2 和 ADH1B 多态性调节的遗传性酒精敏感性作为日本员工精神障碍的指标
DOI：
10.1093/alcalc/agu080
复制
发表时间：
2015
影响因子：
2.8
通讯作者：
Kazuhisa Miyashita
中科院分区：
文献类型：
--
作者：
Kouichi Yoshimasu;Kanae Mure;Marowa Hashimoto;Shigeki Takemura;Kanami Tsuno;Mariko Hayashida;Kenji Kinoshita;Tatsuya Takeshita;Kazuhisa Miyashita
酒精相关性精神障碍（ARD）已被证明伴有多种其他共病精神障碍。本研究评估了各种精神疾病和遗传酒精sensitivity.MethodsA共1944日本工人之间的关联进行了采访，关于他们的精神疾病的迷你国际神经精神访谈（M.I.N.I.）。我们研究了ADH 1Brs 1229984和ALDH 2 rs671多态性与精神障碍风险的关系。Logistic回归分析用于评估这些多态性和精神障碍之间的关联，调整性别，年龄，和jobrank.ResultsThe程度的酒精敏感性分为5组根据组合的ADH 1和ALDH 2基因型（组I-V，从最低的酒精敏感性开始）。与以ALDH 2 * 1/* 2和ADH 1B *1/*2，*2/* 2为参照的受试者相比，ALDH 2 * 1/* 1和ADH 1B *1/* 1或ALDH 2 *1/* 1和ADH 1B *1/*2，* 2/*2（低敏感性）与ARD风险增加显著或接近显著相关。那些ALDH 2 *1/* 1和ADH 1B *1/* 1的患者也有可能增加除ARD以外的任何精神障碍的风险，以及没有合并ARD的精神障碍。女性（OR 11.94，95%CI 0.73-195.63）和非饮酒者（OR 5.43，95%CI 1.05-28.23）的这种倾向更为明显。不饮酒者或ALDH 2 *1/* 1和ADH 1B *1/* 1的女性可能患有除ARD以外的任何精神障碍。
AimsAlcohol-related disorders (ARD) have been shown to be accompanied by a variety of other comorbid mental disorders. This study evaluated the associations between a variety of mental disorders and genetic alcohol sensitivity.MethodsA total of 1944 Japanese workers were interviewed regarding their mental disorders by the Mini-International Neuropsychiatric Interview (M.I.N.I.). We investigated the relationship ofADH1Brs1229984 andALDH2rs671 polymorphisms' combination with mental disorder risks. Logistic regression analysis was used to evaluate the associations between those polymorphisms and mental disorders, adjusting for sex, age, and job rank.ResultsThe degree of alcohol sensitivity was classified into five groups according to the combination ofADH1BandALDH2genotypes (Group I–V in order starting from the lowest alcohol sensitivity). Those withALDH2*1/*1andADH1B*1/*1or withALDH2*1/*1andADH1B*1/*2,*2/*2(low sensitivity) were significantly or nearly significantly associated with an increased risk of ARD compared with those withALDH2*1/*2andADH1B*1/*2,*2/*2as a reference. Those withALDH2*1/*1andADH1B*1/*1were also likely to be at an increased risk of any mental disorder except ARD, as well as disorders without comorbid ARD. This tendency was more apparent among women (OR 11.94, 95% CI 0.73–195.63) and non-drinkers (OR 5.43, 95% CI 1.05–28.23).ConclusionThe genotype combination ofALDH2*1/*1andADH1B*1/*1is significantly associated with an increased risk of any mental disorder, especially ARD. Non-drinkers or women withALDH2*1/*1andADH1B*1/*1are likely to suffer from any mental disorder except ARD.