Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle.

Molecular properties of dihydropyridine-sensitive calcium channels in skeletal muscle.
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骨骼肌中二氢吡啶敏感钙通道的分子特性。

DOI:
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发表时间:
1988
影响因子:
4.8
通讯作者:
Masafumi Takahashi
Masafumi Takahashi
中科院分区:
生物学2区
文献类型:
--
作者:
W. Catterall;Michael Seagar;Masafumi Takahashi

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电压敏感钙通道在膜电位的瞬时变化和各种细胞反应之间提供了重要的联系。在神经元中,钙流入将膜去极化与突触末端的递质释放耦合起来 [1],而在细胞体中,它可能激活钙依赖性钾通道,从而调节重复放电模式 [2]。在心脏和平滑肌组织中,钙通道介导兴奋-收缩耦合,尽管在骨骼肌中钙通道的生理作用仍然存在争议[3,4]。
Voltage-sensitive calcium channels provide an essential link between transient changes in membrane potential and a variety of cellular responses. In neurons, calcium influx couples membrane depolarization to transmitter release at the synaptic terminal [1], whereas in the cell body it may activate calcium-dependent potassium channels and thus modulate repetitive firing patterns [2]. In cardiac and smooth muscle tissue, calcium channels mediate excitation-contraction coupling, although in skeletal muscle their physiological role is still a matter for debate [3,4].
DOI: 10.1073/pnas.84.15.5478
发表时间: 1987-08-01
影响因子: 11.1
作者:
TAKAHASHI, M;SEAGAR, MJ;CATTERALL, WA
通讯作者: CATTERALL, WA
DOI: 10.1126/science.2436296
发表时间: 1987
期刊: Science (New York, N.Y.)
影响因子: --
作者:
Takahashi,M;Catterall,WA
通讯作者: Catterall,WA
心脏和骨骼肌膜中二氢吡啶敏感的钙通道:针对α亚基的抗体的研究。
DOI: 10.1021/bi00391a046
发表时间: 1987
期刊: Biochemistry
影响因子: 2.9
作者:
Takahashi,M;Catterall,WA
通讯作者: Catterall,WA