Ebola haemorrhagic fever.
Ebola haemorrhagic fever.
复制标题
DOI：
10.1016/s0140-6736(10)60667-8
复制
发表时间：
2011-03-05
期刊：
影响因子：
168.9
通讯作者：
Geisbert, Thomas W.
中科院分区：
文献类型：
--
作者：
Feldmann, Heinz;Geisbert, Thomas W.
埃博拉病毒是一种严重的人类病毒性出血热的病原体，称为埃博拉出血热，在中非地区流行。唯一的例外是莱斯顿埃博拉病毒，它与人类疾病无关，在菲律宾发现。埃博拉病毒是非洲当地一个重要的公共卫生威胁，通过输入性感染和对滥用于生物恐怖主义的恐惧而产生全球影响。埃博拉病毒被认为对非洲的类人猿种群也有不利影响。非洲物种在人类中的病死率高达90%，没有预防或治疗方法。埃博拉病毒感染的特征是免疫抑制和全身炎症反应，导致血管、凝血和免疫系统受损，导致多器官衰竭和休克，因此在某些方面类似于脓毒性休克。
Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man, designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The exception is the species Reston Ebola virus, which has not been associated with human disease and is found in the Philippines. Ebola virus constitutes an important local public health threat in Africa, with a worldwide effect through imported infections and through the fear of misuse for biological terrorism. Ebola virus is thought to also have a detrimental effect on the great ape population in Africa. Case-fatality rates of the African species in man are as high as 90%, with no prophylaxis or treatment available. Ebola virus infections are characterised by immune suppression and a systemic inflammatory response that causes impairment of the vascular, coagulation, and immune systems, leading to multiorgan failure and shock, and thus, in some ways, resembling septic shock.