Genetic overlap between bipolar illness and event-related potentials
Genetic overlap between bipolar illness and event-related potentials
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DOI：
10.1017/s003329170600972x
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发表时间：
2007-05-01
影响因子：
6.9
通讯作者：
Murray, Robin M.
中科院分区：
文献类型：
--
作者：
Hall, Mei-Hua;Rijsdijk, Fruhling;Murray, Robin M.
背景与精神分裂症相比，双相情感障碍的电生理内表型研究较少。双相情感障碍的事件相关电位（ERP）的双胞胎研究尚未报道。本研究采用双胞胎设计和先进的遗传模型拟合分析，旨在（1）评估和量化一系列ERP成分与双相情感障碍和精神病特征的关系，（2）检查这种关系的来源（由于遗传或环境因素）。对10对不一致同卵双相双胞胎、6对一致同卵双相双胞胎和78对对照双胞胎进行了P300、P50抑制和失匹配负波（MMN）记录。统计分析基于结构方程模型。双相情感障碍与较小的P300振幅和降低的P50抑制显著相关。遗传相关是主要的关联来源，估计为-0.33 P300振幅和0.46 P50比率。个体特异性环境影响不显著。MMN和P300潜伏期与疾病无关。本研究结果为P300波幅和P50抑制率是双相情感障碍的ERP内表型提供了支持性证据。
Background. Electrophysiological endophenotypes are far less explored in bipolar disorder as compared to schizophrenia. No previous twin study of event-related potentials (ERPs) in bipolar illness has been reported. This study uses a twin design and advanced genetic model fitting analyses aiming to (1) assess and quantify the relationship of a range of ERP components with bipolar disorder with psychotic features, and (2) examine the source of the relationship (due to genetic or environmental factors).Method. P300, P50 suppression and mismatch negativity (MMN) were recorded in 10 discordant monozygotic (MZ) bipolar twin pairs, six concordant MZ bipolar twin pairs and 78 control twin pairs. Statistical analyses were based on structural equation modelling.Results. Bipolar disorder was significantly associated with smaller P300 amplitude and decreased P50 suppression. Genetic correlations were the main source of the associations, estimated to be -0.33 for P300 amplitude and 0.46 for P50 ratio. Individual-specific environmental influences were not significant. MMN and P300 latency were not associated with the illness.Conclusions. The results provide supporting evidence that P300 amplitude and P50 suppression ratio are ERP endophenotypes for bipolar disorder.