PLASMODIUM FALCIPARUM RESISTANT TO CHLOROQUINE IN CAMBODIA
PLASMODIUM FALCIPARUM RESISTANT TO CHLOROQUINE IN CAMBODIA
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DOI：
10.4269/ajtmh.1963.12.840
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发表时间：
1963-01-01
影响因子：
3.3
通讯作者：
SANDOSHAM, AA
中科院分区：
文献类型：
--
作者：
EYLES, DE;HOO, CC;SANDOSHAM, AA
在柬埔寨西部的拜林县，对三例氯喹耐药性疟疾病例进行了研究，这些人在有限的时间内接触蚊子叮咬感染而感染了恶性疟原虫。得出疟疾对氯喹没有正常反应的结论的依据是：（1）氯喹预防后发生疟疾发作，（2）使用同一药物的正常治疗方案后复发。在1例病例中，在存在通常被认为具有治疗作用的血浆水平的情况下复发两次。其中一个病例似乎对乙胺嘧啶也有抗药性。由于未使用乙胺嘧啶，因此未在其他两个案件中研究这一点。
Three cases of chloroquine-resistant malaria were studied in persons who contracted Plasmodium falciparum while exposed to infection by mosquito bite for a limited time in the Paillin District of Western Cambodia. The basis for the conclusion that the malaria did not respond normally to chloroquine was that (1) attacks occurred following chloroquine prophylaxis, and (2) relapses occurred following normal therapeutic regimens with the same drug. In one case, relapse occurred twice in the presence of plasma levels generally considered to be therapeutic. One of the cases appeared to be resistant to pyrimethamine also. This point was not studied in the other two cases because pyrimethamine was not used.