Male-male competition magnifies inbreeding depression in wild house mice
Male-male competition magnifies inbreeding depression in wild house mice
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DOI：
10.1073/pnas.060284797
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发表时间：
2000-03-28
影响因子：
11.1
通讯作者：
Potts, WK
中科院分区：
文献类型：
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作者：
Meagher, S;Penn, DJ;Potts, WK
近亲繁殖对脊椎动物的有害影响在实验室的生命周期的早期阶段有很好的记录。然而，近亲繁殖对野生脊椎动物长期生存和繁殖成功（达尔文适应性）的影响尚不确定。在这里，我们报告了脊椎动物的直接实验证据，表明竞争会增加近亲繁殖对后代生存和繁殖的有害影响。我们比较了适合的近交（从furl-sib交配）和远交野生家鼠（小家鼠）在大，自然的外壳。近亲繁殖的雄性由于竞争力和生存能力都很差，其后代存活率只有远系繁殖的雄性的五分之一。在实验室条件下，近亲繁殖对雄性生殖成功的影响相对较小，对生存率没有影响。半自然条件下没有增加近亲繁殖抑郁症的女性，可能是因为女性没有竞争任何关键资源。近亲繁殖导致的适应性总体下降了57%，是实验室先前估计的4.5倍。这些结果对医学、保护、进化生物学和功能基因组学具有重要意义。
The detrimental effects of inbreeding on vertebrates are well documented for early stages of the life cycle in the laboratory. However, the consequences of inbreeding on long-term survival and reproductive success (Darwinian fitness) are uncertain for vertebrates in the wild. Here, we report direct experimental evidence for vertebrates that competition increases the harmful effects of inbreeding on offspring survival and reproduction. We compared the fitness of inbred (from furl-sib matings) and outbred wild house mice (Mus domesticus) in large, seminatural enclosures. Inbred males sired only one-fifth as many surviving offspring as outbred mates because of their poor competitive ability and survivorship. In laboratory conditions, inbreeding had relatively minor effects on male reproductive success and no effect on survivorship. Seminatural conditions did not increase inbreeding depression for females, probably because females were not competing for any critical resources. The overall reduction in fitness from inbreeding was 57%, which is 4.5 times as great as previous estimates from the laboratory. These results have important implications for medicine, conservation, evolutionary biology, and functional genomics.