Liver stiffness measured by virtual touch quantification predicts the occurrence of posthepatectomy refractory ascites in patients with hepatocellular carcinoma
Liver stiffness measured by virtual touch quantification predicts the occurrence of posthepatectomy refractory ascites in patients with hepatocellular carcinoma
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虚拟触摸量化测量的肝脏硬度可预测肝细胞癌患者肝切除术后难治性腹水的发生
DOI：
10.1007/s00595-021-02392-5
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发表时间：
2021
期刊：
影响因子：
2.5
通讯作者：
Hatano Etsuro
中科院分区：
文献类型：
--
作者：
Toriguchi Kan;Miyashita Seikan;Kawabata Yusuke;Kurimoto Ami;Okuno Masayuki;Iwama Hideaki;Iida Kenjiro;Okamoto Tomohiro;Sueoka Hideaki;Tada Masaharu;Nakamura Ikuo;Fujimoto Yasuhiro;Nishimura Takashi;Iijima Hiroko;Hatano Etsuro
目的本研究评估肝切除术前使用虚拟触摸量化测量肝脏硬度对预测肝切除术后难治性腹水的意义。方法对267例肝细胞癌行肝切除术患者进行前瞻性分析。肝脏刚度定义为基于声无线电力脉冲的虚拟触摸量化的中位数（Vs; m/s）。结果多因素分析显示Vs和天冬氨酸转氨酶血小板比指数是术后难治性腹水的独立危险因素（优势比分别为3.27和3.08）。通过对患者工作特征曲线的分析确定Vs的截止值为1.52 m/s（灵敏度为59.5%，特异性为88.6%），患者工作特征曲线下面积为0.79。天冬氨酸转氨酶与血小板比值的临界值为0.952（敏感性为65.5%，特异性为82.9%），受体工作特征曲线下面积为0.75。结论svs是肝切除术后难治性腹水的独立危险因素。肝切除术前通过虚拟触摸量化测量肝脏硬度有助于估计术后难治性腹水的风险。对于难治性腹水高危患者，应考虑非手术治疗。
PurposeThis study assessed the significance of measuring liver stiffness using virtual touch quantification before hepatectomy to predict posthepatectomy refractory ascites.MethodsA total of 267 patients with hepatocellular carcinoma who underwent hepatectomy were prospectively analyzed. Liver stiffness was defined as the median value of the virtual touch quantification (Vs; m/s) by acoustic radio-force-impulse-based virtual touch.ResultsA multivariate analysis showed that Vs and the aspartate aminotransferase-to-platelet ratio index were independent risk factors for postoperative refractory ascites (odds ratio = 3.27 and 3.08, respectively). The cutoff value for Vs was 1.52 m/s (sensitivity: 59.5%, specificity: 88.6%) as determined by the analysis of the receiver-operating characteristic curve, and the area under the receiver-operating characteristic curve was 0.79. The cutoff value for the aspartate aminotransferase-to-platelet ratio was 0.952 (sensitivity: 65.5%, specificity: 82.9%), and the area under the receiver-operating characteristic curve was 0.75.ConclusionsVs is an independent risk factor for refractory ascites after hepatectomy. The measurement of liver stiffness by virtual touch quantification before hepatectomy can help estimate the risk of postoperative refractory ascites. Nonsurgical treatments should be considered for the management of patients who are at high risk for refractory ascites.
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DOI：
10.1007/978-3-642-37078-6_144
发表时间：
2015-01-23
期刊：
PanVascular Medicine
影响因子：
--
作者：
Morales-Ruiz M;Rodríguez-Vita J;Ribera J;Jiménez W
通讯作者：
Jiménez W
影响因子：
4.2
作者：
Nanashima, Atsushi;Sakamoto, Ayami;Nagayasu, Takeshi
通讯作者：
Nagayasu, Takeshi
DOI：
10.1016/s0015-6264(78)80335-6
发表时间：
1986
期刊：
The New Zealand medical journal
影响因子：
--
作者：
D. Woodfield
通讯作者：
D. Woodfield
影响因子：
29.4
作者：
Song, TJ;Ip, EWK;Fong, YM
通讯作者：
Fong, YM
肝硬化合并肝细胞癌患者的肝切除术后难治性腹水：克服这一有问题的并发症的危险因素分析。
影响因子：
2
作者：
S. Itoh;H. Uchiyama;Y. Ikeda;K. Morita;N. Harada;K. Sugimachi;H. Kawanaka;D. Korenaga;T. Yoshizumi;K. Takenaka;Y. Maehara
通讯作者：
Y. Maehara