Do Vaccines Need a Gender Perspective? Influenza Says Yes!
Do Vaccines Need a Gender Perspective? Influenza Says Yes!
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DOI：
10.3389/fimmu.2021.715688
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发表时间：
2021
影响因子：
7.3
通讯作者：
Sanz-Muñoz I
中科院分区：
文献类型：
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作者：
Sánchez-de Prada L;Ortiz de Lejarazu-Leonardo R;Castrodeza-Sanz J;Tamayo-Gómez E;Eiros-Bouza JM;Sanz-Muñoz I
免疫反应的性别差异是众所周知的。然而，由于研究结果不一致，因此尚未确定男性和女性接种流感疫苗后的体液反应。在2，243名受试者（46.9%为男性）中进行了一项回顾性研究，按年龄（15-64岁和≥65岁）划分。在2006-2018年季节期间接种疫苗的人群中，在每年接种季节性流感病毒疫苗之前和之后28天，通过血凝抑制试验（HI）进行血清学分析。比较了年轻人和老年人中男性和女性个体对疫苗中所含甲型和B型流感病毒的体液应答。在血清转换率方面，发现老年妇女对经典甲型流感（H1N1）、甲型流感（H1N1）pdm 09亚型和B/维多利亚谱系的体液应答显著更高。在A（H3 N2）亚型中没有发现显著差异。老年妇女似乎比老年男子显示出对经典A（H1N1）、大流行A（H1N1）pmd 09和B/维多利亚谱系的更大的体液应答。两性异形不影响年轻的成年人。
Sex differences in immune responses are well known. However, the humoral response in males and females in the case of influenza vaccination is yet to be characterized since studies have shown uneven results. A retrospective study was conducted in 2,243 individuals (46.9% males) divided by age (15–64 and ≥65 years old). A serological analysis was performed by hemagglutination inhibition assay (HI) just before and 28 days after annual vaccination against seasonal influenza viruses in people vaccinated during the 2006–2018 seasons. A comparison of the humoral responses against influenza A and B viruses contained in the vaccine, between male and female individuals in young adults and elderly was conducted. Significative higher humoral response against classical influenza A (H1N1), A(H1N1)pdm09 subtype and B/Victoria lineage in terms of seroconversion rate were found in elderly women. No significant differences were found in the case of A(H3N2) subtype. Elderly women seem to display a greater humoral response against classical A(H1N1), pandemic A(H1N1)pmd09 and B/Victoria lineage than elderly men. Sex dimorphism does not affect young adults.