EFFECT OF AGE ON SENSITIVITY TO PAIN AND BRAIN OPIATE RECEPTORS
EFFECT OF AGE ON SENSITIVITY TO PAIN AND BRAIN OPIATE RECEPTORS
复制标题
DOI：
10.1016/0197-4580(81)90059-2
复制
发表时间：
1981-01-01
影响因子：
4.2
通讯作者：
ROTH, GS
中科院分区：
文献类型：
--
作者：
HESS, GD;JOSEPH, JA;ROTH, GS
在2-3、6-12和24个月的大鼠组中，观察到对热和电击诱导的疼痛的敏感性存在与疼痛相关的差异。年龄。这些年龄差异至少部分被纳洛酮治疗消除，表明衰老过程中内源性阿片系统可能发生变化。与老年动物较高的疼痛阈值相反，额叶、纹状体和海马中阿片受体的浓度降低。随着年龄的增长，前皮质和杏仁核呈现出浓度降低的趋势，但这并不显著。在检查的任何大脑区域中，结合亲和力都没有发生年龄变化。改变受体和反应之间的明显差异的可能解释包括老年大鼠内源性阿片类物质水平较高，疼痛敏感性的大脑区域以外的其他检查，内在的困难，试图本地化的年龄变化在一个单一的步骤，在这样一个复杂的过程中，可能是不同的脊髓通路介导的各种类型的疼痛。
Age-related differences in sensitivity to pain as induced by heat and electrical shock were seen among groups of rats, 2-3, 6-12 and 24 mo. of age. These age differences were at least partially obliterated by naloxone treatment, suggesting that changes may occur in the endogenous opioid system during aging. In contrast to higher pain thresholds in older animals are decreased concentrations of opiate receptors in the frontal poles, striatum and hippocampus. Anterior cortex and amygdala exhibit a trend toward decreased concentration with increased age, but this is not significant. No age changes in binding affinity occur in any of the brain regions examined. Possible explanations for the apparent discrepancy between altered receptors and response include higher endogenous opioid levels in aged rats, mediation of pain sensitivity by brain regions other than those examined, difficulties inherent in attempting to localize age changes at a single step in such a complex process, and possibly differential spinal pathways mediating the various types of pain.