Visualizing Hydrogen Sulfide in Mitochondria and Lysosome of Living Cells and in Tumors of Living Mice with Positively Charged Fluorescent Chemosensors
Visualizing Hydrogen Sulfide in Mitochondria and Lysosome of Living Cells and in Tumors of Living Mice with Positively Charged Fluorescent Chemosensors
复制标题
使用带正电荷的荧光化学传感器可视化活细胞线粒体和溶酶体以及活小鼠肿瘤中的硫化氢
DOI：
10.1021/acs.analchem.6b02459
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发表时间：
2016-09-20
影响因子：
7.4
通讯作者：
Tang, Xinjing
中科院分区：
文献类型：
--
作者：
Wu, Zhisheng;Liang, Duanwei;Tang, Xinjing
Two fluorescent chemosenors, Mito-HS and Lyso-HS, were rationally designed and synthesized with positive charge at physiological conditions. The positive charge showed triple functions as target moieties for subcellular mitochondria and lysosome of living cells, soluble moieties for chemosenors, as well as effective sequesters of HS- (H2S at physiological conditions). These two probes showed faster and more efficient fluorescence H2S detection than the similar literature-reported probe without positive charge. In addition,, visualizing of hydrogen sulfide in tumors of living mice was successfully achieved for the first time using the probe Mito-HS.
