Arterial Spin Labeling to Determine Tumor Viability in Head and Neck Cancer Before and After Treatment
Arterial Spin Labeling to Determine Tumor Viability in Head and Neck Cancer Before and After Treatment
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DOI：
10.1002/jmri.24421
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发表时间：
2014-10-01
影响因子：
4.4
通讯作者：
Shirato, Hiroki
中科院分区：
文献类型：
--
作者：
Fujima, Noriyuki;Kudo, Kohsuke;Shirato, Hiroki
目的：目的：探讨动脉自旋标记（ASL）技术在头颈部恶性肿瘤治疗中应用的可行性，并比较治疗前后肿瘤血流量的变化，以及治疗后肿瘤血流量及其减少率。材料与方法：22例头颈部肿瘤患者在非手术治疗前后使用ASL进行3.0-T磁共振成像（MRI）评估。使用具有Look-Score读出的脉冲ASL序列来计算定量TBF。还计算了治疗前和治疗后值之间的TBF降低率。结果：治疗前和治疗后的平均TBF值分别为121.4 +/- 27.8（标准差）和24.9 +/- 14.9 mL/100 g/min。治疗前后TBF差异有统计学意义。有残留肿瘤的患者治疗后TBF（5例患者，46.9 +/- 7.1 mL/100 g/min）显著高于无残留肿瘤的患者（17例患者，18.4 +/- 9.2 mL/100 g/min）。有肿瘤残留者TBF减少率（0.54 ± 0.55 ± 0.12 ± 0.12）显著低于无肿瘤残留者（0.85 ± 0.06）。ASL可用于头颈部癌中肿瘤活力的非侵入性评估。
Purpose: To evaluate the feasibility of arterial spin-labeling (ASL) in head and neck cancer for noninvasive measurement of tumor blood flow (TBF), by comparing 1) the TBF change before and after the treatment, and 2) posttreatment TBF and its reduction rate between residual and nonresidual tumors after treatment.Materials and Methods: Twenty-two patients with head and neck cancer were evaluated using ASL on 3.0-T magnetic resonance imaging (MRI) before and after nonsurgical treatment. A pulsed ASL sequence with Look-Locker readout was used to calculate quantitative TBF. TBF reduction rates between pre- and posttreatment values were also calculated. Residual tumors were confirmed when present with either histopathologically or clinical follow-up.Results: Pre- and posttreatment mean TBF values were 121.4 +/- 27.8 (standard deviation) and 24.9 +/- 14.9 mL/100g/min, respectively. Pre-and posttreatment TBF differed significantly. Posttreatment TBF was significantly higher in patients with residual tumors (five patients, 46.9 +/- 7.1 mL/100g/min) than in those without (17 patients, 18.4 +/- 9.2 mL/100g/min). The TBF reduction rate was significantly lower in patients with residual tumors (0.540.55 +/- 0.120.12) than in those without (0.85 +/- 0.06).Conclusion: ASL allows quantitative assessment of TBF in head and neck cancer. ASL may be useful for noninvasive assessment of tumor viability in head and neck cancer.