Drug loaded magnetic nanoparticles for cancer therapy
Drug loaded magnetic nanoparticles for cancer therapy
复制标题
DOI：
10.1088/0953-8984/18/38/s24
复制
发表时间：
2006-09-27
影响因子：
2.7
通讯作者：
Alexiou, C.
中科院分区：
文献类型：
--
作者：
Jurgons, R.;Seliger, C.;Alexiou, C.
磁性纳米粒子在生物医学领域的应用已经有30多年的历史。在医学上，它们用于几种方法，如磁性细胞分离或磁共振成像（MRI）。开发生物相容性纳米药物递送系统用于治疗剂的特异性靶向是医学研究的焦点，特别是用于治疗癌症和血管系统疾病。在一个实验性癌症模型中，我们进行了靶向药物递送，并使用磁性氧化铁纳米颗粒，结合到化疗剂，通过外部磁场吸引到兔子的实验性肿瘤（磁性药物靶向）。可以实现肿瘤完全缓解。这些载体的一个重要优点是在用普通成像技术处理后检测这些纳米颗粒的可能性（即，e. X射线断层摄影术、磁弛豫测量法、磁共振成像），其可以与组织学相关联。
Magnetic nanoparticles have been investigated for biomedical applications for more than 30 years. In medicine they are used for several approaches such as magnetic cell separation or magnetic resonance imaging ( MRI). The development of biocompatible nanosized drug delivery systems for specific targeting of therapeutics is the focus of medical research, especially for the treatment of cancer and diseases of the vascular system. In an experimental cancer model, we performed targeted drug delivery and used magnetic iron oxide nanoparticles, bound to a chemotherapeutic agent, which were attracted to an experimental tumour in rabbits by an external magnetic field ( magnetic drug targeting). Complete tumour remission could be achieved. An important advantage of these carriers is the possibility for detecting these nanoparticles after treatment with common imaging techniques ( i. e. x- ray- tomography, magnetorelaxometry, magnetic resonance imaging), which can be correlated to histology.