Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins
Ran GTPase protein promotes human pancreatic cancer proliferation by deregulating the expression of Survivin and cell cycle proteins
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Ran GTPase 蛋白通过解除 Survivin 和细胞周期蛋白的表达来促进人胰腺癌增殖。
DOI：
10.1016/j.bbrc.2013.09.079
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发表时间：
2013-10-18
影响因子：
3.1
通讯作者：
Guo, Xuegang
中科院分区：
文献类型：
--
作者：
Deng, Lin;Lu, Yuanyuan;Guo, Xuegang
Ran 是 Ras GTPase 家族的成员，在核质运输中发挥着重要作用。在此，我们检测了胰腺癌中的 Ran 表达，并探讨了其在肿瘤进展中的潜在作用。发现胰腺癌组织中过度表达的 Ran 与组织学分级高度相关。 Ran 的下调导致细胞增殖的显着抑制、细胞周期停滞在 G1/S 期并诱导细胞凋亡。体内研究也验证了这一结果。进一步的研究表明，这些效应至少部分是由 Cyclin A、Cyclin D1、Cyclin E、CDK2、CDK4、磷酸化 Rb 和 Survivin 蛋白的下调以及切割的 Caspase-3 的上调介导的。 Crown 版权所有 (C) 2013 由 Elsevier Inc. 出版。保留所有权利。
Ran, a member of the Ras GTPase family, has important roles in nucleocytoplasmic transport. Herein, we detected Ran expression in pancreatic cancer and explored its potential role on tumour progression. Overexpressed Ran in pancreatic cancer tissues was found highly correlated with the histological grade. Downregulation of Ran led to significant suppression of cell proliferation, cell cycle arrest at the G1/S phase and induction of apoptosis. In vivo studies also validated that result. Further studies revealed that those effects were at least partly mediated by the downregulation of Cyclin A, Cyclin D1, Cyclin E, CDK2, CDK4, phospho-Rb and Survivin proteins and up regulation of cleaved Caspase-3. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.