A functional role for adenosine A3 receptors:: modulation of synaptic plasticity in the rat hippocampus
A functional role for adenosine A3 receptors:: modulation of synaptic plasticity in the rat hippocampus
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DOI：
10.1016/s0304-3940(01)01633-0
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发表时间：
2001-04-13
影响因子：
2.5
通讯作者：
Ribeiro, JA
中科院分区：
文献类型：
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作者：
Costenla, AR;Lopes, LV;Ribeiro, JA
腺苷通过激活A(1)和A（2A）受体调节海马突触可塑性，即长期增强（LTP）和长期抑制（LTD）。我们现在报告了最近描述的腺苷a(3)受体在海马切片CA1区域突触可塑性调节中的新作用。(1-[2-氯-6-[[（3-碘苯基）甲基]氨基]- 9h -purin-p-yl]-1-脱氧- n-甲基- β -d -核糖呋喃脲胺（CI-IBMECA） （100 nM）激活腺苷A(3)受体增加了θ -burst诱导的LTP（从对照溶液中的1.2 +/- 0.6%增加到CI-IBMECA存在时的25.5 +/- 0.8%）和减弱的LTD（从对照溶液中的30.0 +/- 5.5%减少到CI-IBMECA存在时的13.6 +/- 6.6%）。选择性腺苷A(3)受体拮抗剂MRS 1191 （5-10 μ m）可以阻止CI-IBMECA的作用，这些发现表明腺苷A(3)受体在突触可塑性调节中的功能作用。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Adenosine modulates hippocampal synaptic plasticity, namely long-term potentiation (LTP) and long-term depression (LTD), through activation of A(1) and A(2A) receptors. We now report a novel role for the recently described adenosine A(3) receptor in the regulation of synaptic plasticity in the CA1 area of hippocampal slices. Activation of adenosine A(3) receptors by (1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-p-yl]-1-deoxy-N-methyl-beta -D-ribofuranuronamide (CI-IBMECA) (100 nM) increased the magnitude of theta -burst induced LTP (from 1.2 +/- 0.6% in the control solution to 25.5 +/- 0.8% in the presence of CI-IBMECA) and attenuated LTD (from 30.0 +/- 5.5% decrease in the control solution to 13.6 +/- 6.6% decrease in the presence of CI-IBMECA). The selective adenosine A(3) receptor antagonist, MRS 1191 (5-10 muM), prevented the effects of CI-IBMECA, These findings indicate a functional role for adenosine A(3) receptors in the modulation of synaptic plasticity. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.