INCREASED SENSITIVITY OF THE OSMOTIC CONTROL OF VASOPRESSIN IN SHEEP WITH DEOXYCORTICOSTERONE ACETATE-INDUCED HYPERTENSION
INCREASED SENSITIVITY OF THE OSMOTIC CONTROL OF VASOPRESSIN IN SHEEP WITH DEOXYCORTICOSTERONE ACETATE-INDUCED HYPERTENSION
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DOI：
10.1677/joe.0.1070309
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发表时间：
1985-01-01
影响因子：
4
通讯作者：
BOHR, DF
中科院分区：
文献类型：
--
作者：
BROOKS, DP;SHARE, L;BOHR, DF
醋酸去氧皮质酮（DOCA）诱导的绵羊高血压的发展伴随着加压素的血浆浓度和尿排泄的增加。本文研究了6只绵羊在DOCA诱发高血压之前和之后对渗透压刺激（静脉输注0.85mol/l NaCl，4 ml/min，持续75 min）的加压素反应。在DOCA植入之前，渗透刺激导致血浆渗透压（POSM）从290 ± 0.001增加。1到303 .+-. 1（S.E.M）mosmol/kg H2O和血浆血管加压素浓度（PAVP）为0.23 ± 0.05。0.04至1.07 .+-. 0.15. mu.u./ ml.在DOCA植入后至少30天，当平均动脉血压从81 ± 0.5升高时，3到117 .+-. 5 mmHg时，相同的渗透负荷引起POSM从290 ± 0.5mmHg增加。2到298 .+-. 2 mosmol/kg H2O和PAVP从0.45 ±. 0.05至2.02 . ±. 0.27. mu.u./ ml. POSM与PAVP在各实验中均呈显著相关。然而，在动物发展为高血压后，该关系的斜率显著增加（P < 0.01）（0.185 ± 0.01）。0.026对0.070 ±。0.011（μ u加压素ml）（mosmol/kg H2O））。截获的信息是相似的。DOCA植入物取出后，渗透敏感性恢复正常。
The development of hypertension induced by deoxycorticosterone acetate (DOCA) in sheep was accompanied by increases in both the plasma concentration and the urinary excretion of vasopressin. The vasopressin response to an osmotic stimulus (i.v. infusion of 0.85 mol NaCl/l at 4 ml min for 75 min) was studied before and after the development of hypertension inducd by DOCA in six sheep. Before DOCA implantation, the osmotic stimulus resulted in an increase of plasma osmolality (POSM) from 290 .+-. 1 to 303 .+-. 1 (S.E.M) mosmol/kg H2O and in plasma vasopressin concentration (PAVP) from 0.23 .+-. 0.04 to 1.07 .+-. 0.15 .mu.u./ml. At least 30 days after DOCA implantation when mean arterial blood pressure had risen from 81 .+-. 3 to 117 .+-. 5 mmHg, the same osmotic load caused an increase in POSM from 290 .+-. 2 to 298 .+-. 2 mosmol/kg H2O and PAVP from 0.45 .+-. 0.05 to 2.02 .+-. 0.27 .mu.u./ml. POSM and PAVP were significantly correlated in every experiment. However, the slope of the relationship increased significantly (P < 0.01) after the animals had developed hypertension (0.185 .+-. 0.026 vs. 0.070 .+-. 0.011 (.mu.u. vasopressin ml) (mosmol/kg H2O)). The intercepts were similar. After the DOCA implant had been removed osmotic sensitivity returned to normal.