Neurotrophic factor control of satiety and body weight.
Neurotrophic factor control of satiety and body weight.
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DOI：
10.1038/nrn.2016.24
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Xu B;Xie X
能量平衡，即能量摄入和消耗之间的关系，受到荷尔蒙、大脑回路和周围组织的复杂相互作用的调节。瘦素是一种脂肪细胞衍生的细胞因子，可以抑制食欲，增加能量消耗。具有讽刺意味的是，肥胖者的血浆瘦素水平很高，而且对瘦素治疗有抵抗力。神经营养因子，特别是睫状神经营养因子(CNTF)和脑源性神经营养因子(BDNF)对控制体重也很重要。CNTF可以克服瘦素抵抗以减轻体重，尽管CNTF和Leptin激活了类似的信号级联反应。脑源性神经营养因子基因的突变会导致食欲旺盛和严重肥胖。
Energy balance, the relationship between energy intake and expenditure, is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin is an adipocyte-derived cytokine that suppresses appetite and increases energy expenditure. Ironically, obese individuals have high levels of plasma leptin and are resistant to leptin treatment. Neurotrophic factors, particularly ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF), are also important for the control of body weight. CNTF can overcome leptin resistance to reduce body weight, although CNTF and leptin activate similar signalling cascades. Mutations in the gene for BDNF lead to insatiable appetite and severe obesity.