Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats
Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats
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DOI：
10.1037/0735-7044.111.6.1184
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发表时间：
1997-12-01
影响因子：
1.9
通讯作者：
Phillips, AG
中科院分区：
文献类型：
--
作者：
Duva, CA;Floresco, SB;Phillips, AG
缺血诱导的背侧海马CAI区细胞丢失导致严重的延迟不匹配样本（DNMS）缺陷，而海马切除术产生很少或没有损害，表明部分海马损伤比完全消融对DNMS性能更有害。为了验证这一假设，对有或没有术前DNMS训练的大鼠给予背侧海马的部分细胞毒性损伤。当测试。尽管在CA1和背侧海马体的其它区域中有广泛的细胞损失，但两组都没有显示出任何DNMS缺陷。在最后的实验中，发现先前在DNMS上测试的大鼠在Morris水迷宫上受损。部分海马损伤会破坏空间记忆，而物体识别记忆却完好无损，这一发现表明海马在记忆过程中扮演着特殊的角色。
Ischemia-induced cell loss in the CAI region of thr dorsal hippocampus results in severe deficits on delayed non-matching-to-sample (DNMS), whereas hippocampectomy produces little or no impairment, suggesting that partial hippocampal damage is more detrimental to DNMS performance than total ablation. To test this hypothesis, rats with or without preoperative DNMS training were given partial cytotoxic lesions of the dorsal hippocampus. When tested. neither group displayed any DNMS deficits despite widespread cell loss in the CA1 and other regions of the dorsal hippocampus. In the final experiments, rats tested previously on DNMS were found to be impaired on the Morris water maze. The finding that partial hippocampal lesions disrupt spatial memory while leaving object-recognition memory intact indicates a specialized role for the hippocampus in mnemonic processes.