Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal rats
Distribution of progesterone receptor immunoreactivity in the midbrain and hindbrain of postnatal rats
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DOI：
10.1002/dneu.20664
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发表时间：
2008-10-01
影响因子：
3
通讯作者：
Wagner, Christine K.
中科院分区：
文献类型：
--
作者：
Quadros, Princy S.;Schlueter, Lisa J.;Wagner, Christine K.
核类固醇激素受体是强大的转录因子，因此有可能影响和调节神经发育的基本过程。孕酮受体（PR）的表达已在大鼠和小鼠的发育前脑中得到描述，并且哺乳动物的大脑可能暴露于大量的孕酮，这些孕酮要么来自母体来源，要么来自脑内的胆固醇从头合成孕酮。本研究检查了出生后大鼠中脑和后脑内 PR 免疫反应 (PRir) 细胞的分布。结果表明，PR 在生命的前 2 周内在特定的运动、感觉和网状核心核中短暂表达，尤其是在中脑多巴胺能细胞群（如黑质和腹侧被盖区）内。此外，在菱形下唇细胞中观察到强大的 PRir，这是一种产生小脑前核的瞬时结构。这些结果表明孕激素和孕酮受体可能在许多中脑和后脑核的出生后发育中发挥重要作用，包括与人类疾病有关的一些区域。此外，这些发现有助于越来越多的证据表明类固醇激素及其受体影响广泛的大脑区域的神经发育，包括许多通常与生殖或神经内分泌功能无关的区域。 (C) 2008 年 Wiley 期刊公司。
Nuclear steroid hormone receptors are powerful transcription factors and therefore have the potential to influence and regulate fundamental processes of neural development. The expression of progesterone receptors (PR) has been described in the developing forebrain of rats and mice, and the mammalian brain may be exposed to significant amounts of progesterone, either from maternal sources and/or de novo synthesis of progesterone from cholesterol within the brain. The present study examined the distribution of PR immunoreactive (PRir) cells within the midbrain and hindbrain of postnatal rats. The results demonstrate that PR is transiently expressed within the first 2 weeks of life in specific motor, sensory and reticular core nuclei its well its within midbrain dopaminergic cell groups such as the substantia nigra and the ventral tegmental area. Additionally, robust PRir was observed in cells of the lower rhombic lip, a transient structure giving rise to precerebellar nuclei. These results suggest that progestins and progesterone receptors may play a fundamental role in the postnatal development of numerous midbrain and hindbrain nuclei, including some areas implicated in human disorders. Additionally, these findings contribute to the increasing evidence that steroid hormones and their receptors influence neural development in a wide range of brain areas, including many not typically associated with reproduction or neuroendocrine function. (C) 2008 Wiley Periodicals, Inc.