Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period.
Infant Cardiac Orienting Responses Predict Later FASD in the Preschool Period.
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婴儿心脏定向反应可预测学龄前后期FASD
DOI：
10.1111/acer.14525
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
CIFASD
中科院分区：
文献类型：
--
作者：
Kable JA;Coles CD;Jones KL;Yevtushok L;Kulikovsky Y;Zymak-Zakutnya N;Dubchak I;Akhmedzhanova D;Wertelecki W;Chambers CD;CIFASD
产前酒精暴露（PAE）已被确定为发育障碍的主要可预防原因之一，但早期识别受影响的人一直具有挑战性。本研究评估了婴儿心脏定向反应（CORs）用于预测胎儿酒精谱系障碍（FASD）状态的应用，CORs评估了环境事件的神经生理编码，对PAE的影响敏感。根据母亲的饮酒情况，在怀孕期间招募了来自乌克兰的母子二人组。参与者（n = 120）在6个月和12个月时收集CORs，并在学龄前被分类为：(1)胎儿酒精综合征（FAS），(2)部分FAS (pFAS),(3)酒精相关神经发育障碍（ARND）， (4) PAE但未诊断，或(5)无PAE但未诊断。为了评估CORs，使用固定试验习惯性/非习惯性范式呈现刺激（听觉音调和图像）。心率（HR）反应在前3个习惯化和非习惯化试验中汇总，并转换为相对于样本在刺激下每秒平均反应的z分数。然后按条件（习惯化或不习惯化）计算大于1的z分数，以计算总风险指数。在视觉刺激而非听觉刺激引起的CORs总偏差得分上，组间差异有统计学意义。那些被归类为pFAS/FAS的患者的总偏差评分明显高于那些被归类为ARND或没有酒精相关诊断且有无PAE病史的患者。接受者工作特性曲线分析所得的视觉反应面积曲线下值为。765用于预测pFAS/FAS状态。在婴儿期使用视觉刺激引起的CORs中，反映与典型HR总偏差的评分可能有助于识别因PAE而需要早期干预的个体。
Prenatal alcohol exposure (PAE) has been identified as one of the leading preventable causes of developmental disabilities but early identification of those impacted has been challenging. This study evaluated the use of infant cardiac orienting responses (CORs), which assess neurophysiological encoding of environmental events and are sensitive to the impact of PAE, to predict later Fetal Alcohol Spectrum Disorder (FASD) status. Mother-infant dyads from Ukraine were recruited during pregnancy based on the mother’s use of alcohol. Participants (n = 120) were then seen at 6 and 12 months when CORs were collected and in the preschool period when they were categorized as having (1) fetal alcohol syndrome (FAS), (2) partial FAS (pFAS), (3) alcohol-related neurodevelopmental disorder (ARND), (4) PAE and no diagnosis, or (5) no PAE and no diagnosis. To assess CORs, stimuli (auditory tones and pictures) were presented using a fixed-trial habituation/dishabituation paradigm. Heart rate (HR) responses were aggregated across the first 3 habituation and dishabituation trials and converted to z-scores relative to the sample’s mean response at each second by stimuli. Z-scores greater than 1 were then counted by condition (habituation or dishabituation) to compute a total risk index. Significant group differences were found on total deviation scores of the CORs elicited from visual but not auditory stimuli. Those categorized as pFAS/FAS had significantly higher total deviation scores than did those categorized as ARND or as having no alcohol-related diagnosis with or without a history of PAE. Receiver operating characteristic curve analysis of the visual response yielded an area under the curve value of .765 for predicting to pFAS/FAS status. A score reflecting total deviation from typical HR during CORs elicited using visual stimuli in infancy may be useful in identifying individuals who need early intervention as a result of their PAE.
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影响因子：
3.2
作者：
Chambers, Christina D.;Yevtushok, Lyubov;Wertelecki, Wladimir
通讯作者：
Wertelecki, Wladimir
影响因子：
3.2
作者：
Coles, Claire D.;Gailey, Amanda R.;Jones, Kenneth Lyons
通讯作者：
Jones, Kenneth Lyons
DOI：
10.1097/01.alc.0000117837.66107.64
发表时间：
2004-03-01
影响因子：
3.2
作者：
Kable, JA;Coles, CD
通讯作者：
Coles, CD
影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.
影响因子：
2.9
作者：
Dodge, Neil C.;Jacobson, Joseph L.;Jacobson, Sandra W.
通讯作者：
Jacobson, Sandra W.