High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization
High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization
复制标题
基于单层石墨烯/Au-NPs结构的高性能偏振控制调制表面等离子体共振传感器，用于检测DNA杂交
DOI：
10.1088/1361-6501/ab383a
复制
发表时间：
2019-12-01
影响因子：
2.4
通讯作者：
Wang，Xiaoping
中科院分区：
文献类型：
--
作者：
Sun，Yi;Cai，Haoyuan;Wang，Xiaoping
报道了一种基于单层石墨烯/金纳米颗粒的高灵敏度偏振控制调制等离子体生物传感器，用于单链DNA杂交的直接检测。单层石墨烯在金膜上的存在通过π堆积作用提供了新型的官能化衍生物。此外，通过现场监测单链DNA与Au-NPs之间的在线组装策略，使结合更容易和可量化。强等离激元介导的能量约束的使用诱导了大约30倍的反射光的强场增强。该体系的线性动态范围为10−15~10−7M，用于单链DNA的检测。此外，通过提高对分子结合的敏感性，新的生物传感器可以实现对23聚体单链DNA的500am的超低检测极限。
A highly sensitive polarization control modulated plasmonic biosensor based on monolayer graphene/Au-NPs for direct detection of single-stranded DNA (ssDNA) hybridization is reported. The presence of monolayer graphene on gold film provides novel functionalized derivatives through π-stacking interactions. In addition, the online assembly strategy via in situ monitoring between ssDNA and Au-NPs makes the binding easier and quantifiable. The use of strong plasmon-mediated energy confinements induces an approximately 30-fold intense field enhancement of the reflected light. The architecture exhibits a linear dynamic range of 10−15 to 10−7 M for the detection of target ssDNA. Moreover, the new biosensor can achieve an ultralow detection limit of 500 aM for 23-mer ssDNA via improved sensitivity to molecular bindings.