Head injury, bipolar disorder, and response to valproate.
Head injury, bipolar disorder, and response to valproate.
复制标题
头部受伤、双相情感障碍和对丙戊酸钠的反应。
DOI：
10.1016/0010-440x(88)90035-1
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发表时间：
1988
影响因子：
7.3
通讯作者：
Kalish,R
中科院分区：
文献类型：
--
作者：
PopeJr,HG;McElroy,SL;Satlin,A;Hudson,JI;KeckJr,PE;Kalish,R
两名患者之前都没有症状，在闭合性脑损伤后发展为典型的双相情感障碍的慢性病例。两人对标准治疗的反应都不充分，但在药物治疗方案中加入了抗惊厥药物丙戊酸盐后，情况有所缓解。对另外56名同样接受丙戊酸盐治疗的双相情感障碍患者进行的图表审查发现，又有8名患者有头部损伤史，其中7名患者在之前不足的药物治疗方案中加入丙戊酸盐后有反应。这些观察结果补充了越来越多的数据，这些数据表明，双相情感障碍有时可能是由头部损伤引起的。此外，这类案件似乎需要对丙戊酸盐进行审判。
Two patients, both previously asymptomatic, developed chronic cases of typical bipolar disorder following closed head injury. Both responded inadequately to standard treatment, but remitted when valproate, an anticonvulsant, was added to the medication regimen. A chart review of 56 additional bipolar patients, also treated with valproate, yielded eight more cases with a history of head injury, of whom seven responded when valproate was added to previously inadequate medication regimens. These observations augment the growing data which suggest that bipolar disorder may occasionally be precipitated by head injury. Further, it appears that such cases may warrant a trial of valproate.