The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study
The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study
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DOI：
10.1002/mds.21596
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发表时间：
2007-10-15
影响因子：
8.6
通讯作者：
Schapira, Anthony H. V.
中科院分区：
文献类型：
--
作者：
Chaudhuri, Kallol Ray;Martinez-Martin, Pablo;Schapira, Anthony H. V.
帕金森病（PD）的非运动症状（NMS）很常见，显著降低生活质量，目前还没有经过验证的临床工具来评估NMS的进展或对治疗的潜在反应。本研究编制了一个新的30项帕金森病NMS评定量表（NMSS）。NMSS包含九个维度：心血管、睡眠/疲劳、情绪/认知、知觉问题、注意力/记忆、胃肠、泌尿、性功能和其他。分析了该仪器的计量属性。从欧洲、美国和日本的研究中心收集了242例患者的数据，平均年龄67.2 ± 11岁，疾病持续时间6.4 ± 6年，57.3%为男性，所有PD分期。平均NMSS评分为56.5 +/- 40.7（范围：0-243），只有1例患者宣称无NMS。该量表提供了99.2%的完整数据用于分析，总分无下限和上限效应。令人满意的缩放假设（多特质缩放成功率>95%，除其他领域）和内部一致性报告的大多数领域（平均α，0.61）。因子分析支持了一个先验的9个领域的结构（63%的方差），而一个小的测试-重测研究显示了令人满意的重现性（ICC > 0.80），除了心血管（ICC = 0.45）的所有领域。在有效性方面，该量表显示与运动症状严重程度和疾病进展的指标适度相关，但与NMS的其他测量（NMSQuest）和健康相关生活质量测量（PDQ-8）（两者，rS = 0.70）高度相关。总之，NMSS可用于评估所有阶段PD患者NMS的频率和严重程度，并结合最近验证的非运动问卷。(C)2007年，《社会运动》创刊。
Non-motor symptoms (NMS) in Parkinson's disease (PD) are common, significantly reduce quality of life and at present there is no validated clinical tool to assess the progress or potential response to treatment of NMS. A new 30-item scale for the assessment of NMS in PD (NMSS) was developed. NMSS contains nine dimensions: cardiovascular, sleep/fatigue, mood/cognition, perceptual problems, attention/memory, gastrointestinal, urinary, sexual function, and miscellany. The metric attributes of this instrument were analyzed. Data from 242 patients mean age 67.2 +/- 11 years, duration of disease 6.4 +/- 6 years, and 57.3% male across all stages of PD were collected from the centers in Europe, USA, and Japan. The mean NMSS score was 56.5 +/- 40.7, (range: 0-243) and only one declared no NMS. The scale provided 99.2% complete data for the analysis with the total score being free of floor and ceiling effect. Satisfactory scaling assumptions (multitrait scaling success rate >95% for all domains except miscellany) and internal consistency were reported for most of the domains (mean alpha, 0.61). Factor analysis Supported the a prori nine domain structure (63% of the variance) while a small test-retest study showed satisfactory reproducibility (ICC > 0.80) for all domains except cardiovascular (ICC = 0.45). In terms of validity, the scale showed modest association with indicators of motor symptom severity and disease progression but a high correlation with other measures of NMS (NMSQuest) and healthrelated quality of life measure (PDQ-8) (both, rS = 0.70). In conclusion, NMSS can be used to assess the frequency and severity of NMS in PD patients across all stages in conjunction with the recently validated non-motor questionnaire. (C) 2007 Movement Disorder Society.