The role of nuclear factor-κ B in pulmonary diseases
The role of nuclear factor-κ B in pulmonary diseases
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DOI：
10.1378/chest.117.5.1482
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发表时间：
2000-05-01
期刊：
影响因子：
9.6
通讯作者：
Blackwell, TS
中科院分区：
文献类型：
--
作者：
Christman, JW;Sadikot, RT;Blackwell, TS
核因子-kappaB(NF-kappa B)是一类DNA结合的蛋白因子家族，参与大多数致炎分子的转录，包括黏附分子、酶、细胞因子和趋化因子。在为阐明肺部疾病的病理生物学而发展的各种细胞和动物模型系统中，核因子-kappaB的激活似乎是一个关键的早期事件。这篇简短综述的目的是描述有关核因子-kappa B分子生物学的已知情况，并综述核因子-kappaB在肺部疾病发病机制中的作用，包括ARDS、全身炎症反应综合征、哮喘、呼吸道病毒感染、职业性和环境性肺疾病以及囊性纤维化。
Nuclear factor-kappa B (NF-kappa B) is a family of DNA-binding protein factors that are required for transcription of most proinflammatory molecules, including adhesion molecules, enzymes, cytokines, and chemokines. NF-kappa B activation seems to be a key early event in a variety of cell and animal model systems developed to elucidate the pathobiology of lung diseases. The purpose of this short review is to describe what is known about the molecular biology of NF-kappa B and to review information that implicates NF-kappa B in the pathogenesis of lung disease, including ARDS, systemic inflammatory response syndrome, asthma, respiratory viral infections, occupational and environmental lung disease, and cystic fibrosis.