HABENULAR AND OTHER MIDBRAIN RAPHE AFFERENTS DEMONSTRATED BY A MODIFIED RETROGRADE TRACING TECHNIQUE
HABENULAR AND OTHER MIDBRAIN RAPHE AFFERENTS DEMONSTRATED BY A MODIFIED RETROGRADE TRACING TECHNIQUE
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DOI：
10.1016/0006-8993(77)90291-8
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发表时间：
1977-01-01
期刊：
影响因子：
2.9
通讯作者：
WANG, RY
中科院分区：
文献类型：
--
作者：
AGHAJANIAN, GK;WANG, RY
用辣根过氧化物酶（HRP）逆行转运法研究了大鼠中脑背核和中缝正中核的传入神经。HRP通过一种改良的离子电泳给药技术给药。这种技术允许高浓度的HRP高效和局部沉积到中缝核中。通过这种方法确定的中缝传入事件分为两类：专门针对中缝的传入事件和对相邻网状结构也有积极作用的传入事件。在选择性和密度方面，中缝最显著的传入区是外侧链。这与先前使用退行性变方法的研究一致，该研究表明，韧带投射到中缝区。中缝背核有来自孤立束核的阳性传入信号。大多数其他中缝传入区网状形成阳性（如前额皮质、内侧前脑束、视前核和网状形成）。从侧链到中脑中缝的主要传入系统的存在与背侧通路的概念是一致的，背侧通路可能负责将信息从前脑边缘结构传递到中脑边缘区域。
Afferents to the midbrain dorsal and median raphe nuclei in the rat were studied by the horseradish peroxidase (HRP) retrograde transport method. The HRP was given by a modified iontophoretic delivery technique. This technique permitted an efficient and localized deposition of a high concentration of HRP into the raphe nuclei. Afferents to the raphe as determined by this method were categorized into 2 classes: those exclusively to the raphe and those also positive for adjacent reticular formation. The most striking afferent area to the raphe, both in terms of selectivity and density, was the lateral habenula. This was in accord with previous studies using degeneration methods which indicated an habenular projection to the raphe area. There were afferents exclusively positive for the dorsal raphe nucleus emanating from the nucleus of the solitary tract. Most other raphe afferent areas were also positive for the reticular formation (e.g., prefrontal cortex, medial forebrain bundle, preoptic nuclei and reticular formation). The existence of a major afferent system from the lateral habenula to the midbrain raphe is consistent with the concept of a dorsal pathway which might be responsible for relaying information from forebrain limbic structures to the midbrain limbic areas.