Differential effects of nucleus basalis lesions in young adult and aging rats.
Differential effects of nucleus basalis lesions in young adult and aging rats.
复制标题
年轻成年大鼠和老年大鼠基底核损伤的不同影响。
DOI：
10.1016/s0197-4580(99)00025-1
复制
发表时间：
1999
影响因子：
4.2
通讯作者：
Pelleymounter,MA
中科院分区：
文献类型：
--
作者：
Wellman,CL;Pelleymounter,MA
为了表征额叶皮层可塑性的年龄相关变化，我们评估了青年、中年和老年大鼠的迷宫学习和额叶皮层药理学。大鼠接受鹅膏蕈氨酸或假病灶的基底核大细胞（NBM），然后进行训练的径向迷宫任务。训练后，我们使用定量放射自显影术评估了[3H]去甲基丙咪嗪（DEMETHYMIMPRAMINE，DEMETHYMIMPRAMINE）、[3H]蝇蕈醇、[3H]AMPA和[3H]QNB的结合。中年和老年大鼠在径向迷宫任务中均受损。在中年和老年大鼠中，QNB结合增加，而在老年大鼠中，QNB结合减少。虽然病变损害迷宫性能在所有年龄，中年和老年大鼠表现出更深刻的病变诱导的赤字。病变增加GABA和AMPA受体结合在年轻的成年大鼠。这些病变引起的变化可能反映了随着年龄增长而丧失的代偿反应。
To characterize age-related changes in frontal cortical plasticity, we assessed maze learning and frontal cortical pharmacology in young adult, middle-aged, and aged rats. Rats received either ibotenic acid or sham lesions of the nucleus basalis magnocellularis (NBM) and were then trained on a radial maze task. After training, we assessed [3H]desmethylimipramine (DMI), [3H]muscimol, [3H]AMPA, and [3H]QNB binding using quantitative autoradiography. Both middle-aged and aged rats were impaired on the radial maze task. DMI binding was increased in both middle-aged and aged rats, while QNB binding was decreased in aged rats. While lesions impaired maze performance at all ages, middle-aged and aged rats showed more profound lesion-induced deficits. Lesions increased GABAAand AMPA receptor binding in young adult rats only. These lesion-induced changes may reflect a compensatory response that is lost with advancing age.