Chronic portal hypertension: effects on gastrointestinal blood flow distribution.
Chronic portal hypertension: effects on gastrointestinal blood flow distribution.
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慢性门脉高压：对胃肠道血流分布的影响。
DOI：
10.1152/ajpgi.1986.250.4.g535
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Granger,DN
中科院分区：
文献类型：
--
作者：
Benoit,JN;Womack,WA;Korthuis,RJ;Wilborn,WH;Granger,DN
在假手术对照组和门静脉狭窄大鼠胃肠道壁内血流分布进行了测定。通过放射性微球技术测量的总器官血流量在门脉高压大鼠的食管（66%）、胃（102%）、十二指肠（42%）、空肠（52%）、回肠（54%）和结肠（79%）中升高。组织学评价的非放射性15微米微球允许每个器官的壁（粘膜，粘膜下层和肌层外）内的血流分级。微球分布模式表明，在所有器官的壁内血流分布没有显着影响慢性门静脉高压症。这些发现进一步明确了慢性门脉高压引起胃肠道充血的因素的特点。
The intramural distribution of blood flow in the gastrointestinal tract was measured in shamoperated control and portal vein-stenosed rats. Total organ blood flow, measured via the radioactive microsphere technique, was elevated in the esophagus (66%), stomach (102%), duodenum (42%), jejunum (52%), ileum (54%), and colon (79%) of portal-hypertensive rats. Histological evaluation of carbonized nonradioactive 15-microns microspheres allowed for fractionation of blood flow within the wall (mucosa, submucosa, and muscularis externa) of each organ. The microsphere distribution pattern indicates that intramural blood flow distribution in all organs was not dramatically affected by chronic portal hypertension. These findings further define the characteristics of the factors responsible for the gastrointestinal hyperemia produced by chronic portal hypertension.